AP2S1
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Official Full Name
adaptor-related protein complex 2, sigma 1 subunit -
Overview
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts. -
Synonyms
AP2S1;adaptor-related protein complex 2, sigma 1 subunit;CLAPS2;AP-2 complex subunit sigma;Adapter-related protein complex 2 sigma subunit;Adaptor protein complex AP2 subunit sigma;Adaptor related protein complex 2 sigma 1 subunit;AI043088;AP 17;AP 2 complex subunit sigma 1;AP17;AP17 delta;AP2 complex subunit sigma 1;CLAPS 2;Clathrin adaptor complex AP2, sigma subunit;Clathrin adaptor protein AP17;Clathrin assembly protein 2 small chain;Clathrin associated/assembly/adaptor protein small 2;Clathrin associated/assembly/adaptor protein small 2, 17-KD;Clathrin coat assembly protein AP17;Clathrin coat associated protein AP17;HA2 17 kDa subunit;MGC62945;Plasma membrane adaptor AP 2 17 kDa protein;Plasma membrane adaptor AP-2 17 kDa protein;Plasma membrane adaptor AP2 17 kDa protein;Sigma adaptin 3b;Sigma2 adaptin;sigma2-adaptin;clathrin coat-associated protein AP17;adaptor protein complex AP-2 subunit sigma;plasma membrane adaptor AP-2 17 kDa p;AP17-DELTA
Recombinant Proteins
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- E.coli
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
AP2S1 involved in several pathways and played different roles in them. We selected most pathways AP2S1 participated on our site, such as Adaptive Immune System,Axon guidance,Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | EFNA2A,DPYSL2,SEMA3G,SCN4A,AKAP9,CNKSR1,SPTBN2,GNAI1,ARPC1A,COL6A2 |
| Disease | APOBEC3G,CCDC167,AP1M2,STX1B,CDC37,CYP11A1,PDCD6IP,AP2M1,TCEA1,AMN |
| Developmental Biology | SDCBP,STX1B,MED18,EFNB1,EPHB4A,DPYSL5B,ARPC5,EVL,DPYSL2B,RASGRP1 |
| EPH-ephrin mediated repulsion of cells | EPHA2,EFNB3B,AP2B1,EFNA1,EPHA2A,EPHB4B,CLTB,EFNA4,EFNB3,EFNA2A |
| Adaptive Immune System | ARIH2,PVRL2L,KIF22,Mill2,PPIAL4A,FBXO17,CD300LG,ACTR1A,DYNC1I2,KIF2A |
| Beta-catenin independent WNT signaling | GNB5,RYK,CLTC,CTNNB2,PRICKLE1,AP2A1,AGO1,AGO2,CLTA,AGO3 |
| EGFR downregulation | SPRY2,SPRY1,AP2B1,PTPRK,AP2A2,AP2M1,STAM2,AP2A1 |
| EPH-Ephrin signaling | EFNA5,ACTR2B,DNM1,EFNA1B,SDCBP,EFNB2A,EPHA10,EPHA2,ACTR3,KALRNB |
Protein Function
AP2S1 has several biochemical functions, for example, contributes_to clathrin adaptor activity,protein binding,protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2S1 itself. We selected most functions AP2S1 had, and list some proteins which have the same functions with AP2S1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IRS2,L3MBTL2,POSTN,Serpina1b,IRF5,NTF4,COMP,MED6,KRTAP10-5,SMNDC1 |
| protein transporter activity | IPO7,AP1B1,ZFYVE16,TNPO2,CHMP7,KPNA5,AP4S1,TSNAX,COG2,IPO8 |
| transporter activity | SLC17A9,ABCB11,SLC5A8,SLC37A4B,LCN12,LCN2,AQP3,Abcb1b,SEC22A,TIMM9 |
| contributes_to clathrin adaptor activity | AP2M1,AP2A1,AP2B1,AP2A2 |
Interacting Protein
AP2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2S1.
AAGAB;VCAM1;Ap2a1;vpu;TDGF1;EGFR;CLTB;EPS15;NUMB;Smo;GRB2;AP2M1
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References
- Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).
- Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
