ANXA7
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Official Full Name
annexin A7 -
Overview
Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. -
Synonyms
ANXA7;annexin A7;ANX7;SNX;Synexin;annexin-7;annexin VII
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ANXA7 involved in several pathways and played different roles in them. We selected most pathways ANXA7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ANXA7 has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipid binding,calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA7 itself. We selected most functions ANXA7 had, and list some proteins which have the same functions with ANXA7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-dependent protein binding | SEC31A,CALM2,ANXA4,ANXA1,SYN1,S100P,MMP13,CPNE3,CLEC4M,SYT8 |
| calcium ion binding | MMP25,PCDHA2,ANXA8,RYR3,S100T,S100A7A,CABS1,PLCH1,Npnt,S100G |
| protein binding | METTL21C,MYOCD,NRIP3,SPATA8,TOP2A,DDX18,NCK2,TEAD2,UBE2D1,POLR2A |
| poly(A) RNA binding | XPO5,SLC3A2,SF3A1,RPL7A,RPL10,YTHDC2,PDIA4,RDBP,AASS,HNRPDL |
| integrin binding | IGF1,ITGB1BP1,ICAM5,FBN1,FCER2,ANGPTL3,DMP1,GFAP,CD226,TSPAN8 |
| calcium-dependent phospholipid binding | SYT1B,SYT5B,SYT7B,SYT3,SYT7,ANXA1,C2CD4B,RPH3AL,ANXA3,ANXA13L |
Interacting Protein
ANXA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA7.
SRI;PDCD6;PAX8;q81y32_bacan;DYNC1I1;DVL1;GNB5;ANGPT2;MPPED1;GDF9;NMT2;TAF5L;ACTL6B;CPNE6;DDAH2;F13A1;A2M
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