ANK1
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Official Full Name
ankyrin 1, erythrocytic -
Overview
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. -
Synonyms
ANK1;ankyrin 1, erythrocytic;ANK;ankyrin-1;SPH1;ANK-1;ANK1_HUMAN;Ankyrin 1;Ankyrin R;Ankyrin-R;Erythrocyte ankyrin;SPH2
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- E.coli
- E.Coli or Yeast
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- His
- His&T7
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ANK1-1644M | Recombinant Mouse ANK1 Protein | Mammalian Cell | Mouse | His |
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| ANK1-1730H | Recombinant Human ANK1 protein, His & T7-tagged | E.coli | Human | His&T7 | Leu32~Leu369 |
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| ANK1-3490H | Recombinant Human ANK1, His-tagged | E.Coli or Yeast | Human | His | 1880 |
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| ANK1-561H | Recombinant Human ANK1 protein, GST-tagged | Wheat Germ | Human | GST |
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| ANK1-75HCL | Recombinant Human ANK1 cell lysate | Human | Non |
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| ANK1-1012HF | Recombinant Full Length Human ANK1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 155 amino acids |
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| ANK1-532M | Recombinant Mouse ANK1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ANK1-532M-B | Recombinant Mouse ANK1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ANK1 involved in several pathways and played different roles in them. We selected most pathways ANK1 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | SMAD2,PIK3CB,WNT7A,TNF,CAMK2A,PIK3R3,FLNA,FZD3,PRKACB,SDC1 |
Protein Function
ANK1 has several biochemical functions, for example, ATPase binding,cytoskeletal adaptor activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANK1 itself. We selected most functions ANK1 had, and list some proteins which have the same functions with ANK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| spectrin binding | CAMSAP1,DCTN2,DYNC1I1,PDE6G,SLC26A5,UNC13A,GBP1,MYO7A,SPTAN1,ADD2 |
| enzyme binding | DHCR24,KDM4C,STC2,APBA3,TTN,HSPA1B,IL6R,GSTM2,ATG3,CPSF1 |
| cytoskeletal adaptor activity | ABI2,BICD1,BAIAP2L2,GAS2L1,GAS2L2,BAIAP2L1B,BAIAP2L2B,NCK1,BAIAP2L1A,COX4I2 |
| structural molecule activity | BVES,LCE3E,CYLC1,CLDN7B,CLDN16,LMNB2,CLDN18,COL15A1B,MAP7,CLDN3 |
| structural constituent of cytoskeleton | SPTBN1,TUBE1,SORBS3,EPB41L3,DSP,PLS1,KRT17,SPRR2A1,SPTA1,TUBG1 |
| ATPase binding | FXYD1,ATP6V1G3,ATP6V0A1B,TAF9,RAB4A,FAM119A,TOR1AIP1,PIH1D1,NOP58,LCK |
| protein binding | ARHGEF1,ZZZ3,EPN3,SEPT4,RNPS1,FBXO44,MLL1,CLIP4,RORB,VIP |
Interacting Protein
ANK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANK1.
OBSCN;OBSCN;HSPB1
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References
- Hughes, MR; Anderson, N; et al. A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. EXPERIMENTAL HEMATOLOGY 39:305-320(2011).
- Giacomello, E; Sorrentino, V; et al. Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres. HISTOCHEMISTRY AND CELL BIOLOGY 131:371-382(2009).
