ANAPC4
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Official Full Name
anaphase promoting complex subunit 4 -
Overview
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. -
Synonyms
ANAPC4;anaphase promoting complex subunit 4;anaphase-promoting complex subunit 4;APC4;ANAPC 4;APC 4;APC Complex Protein CUT20;APC4_HUMAN;CUT20;Cyclosome subunit 4;LID1;OTTHUMP00000123382;OTTHUMP00000218479
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ANAPC4-1887Z | Recombinant Zebrafish ANAPC4 | Mammalian Cell | Zebrafish | His |
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| ANAPC4-323R | Recombinant Rhesus monkey ANAPC4 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| ANAPC4-545H | Recombinant Human ANAPC4 protein, GST-tagged | Wheat Germ | Human | GST |
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| ANAPC4-73HCL | Recombinant Human ANAPC4 cell lysate | Human | Non |
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| ANAPC4-151R | Recombinant Rhesus Macaque ANAPC4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ANAPC4-151R-B | Recombinant Rhesus Macaque ANAPC4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
ANAPC4 involved in several pathways and played different roles in them. We selected most pathways ANAPC4 participated on our site, such as Cell cycle,Oocyte meiosis,Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANAPC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | PDGFRA,HLA-C,ANAPC1,WNT6,SLC25A6,ANAPC7,ITGB2,RANBP3,SLC25A31,ATF1 |
| Progesterone-mediated oocyte maturation | MAPK12B,GNAIA,RPS6KA2,Adcy4,MAD2L2,AKT3A,PIK3R3B,PIK3CD,SPDYA,PRKACAB |
| Ubiquitin mediated proteolysis | PIAS1,CDH1-A,UBE2G1,PIAS4,FBXW8,UBE2Z,CDC27,MGRN1A,UBE2R2,CUL3A |
| Oocyte meiosis | PPP2R5A,CALM2,STAG3,RPS6KA3B,ITPR3,PKMYT1,PPP2R5EA,FBXO5,ADCY1A,BTRC |
| Cell cycle | RBBP8,ENSAA,PLK4,H3F3B.1,CEP63,MCM8,WAPAL,ORC2,BUB3,E2F4 |
Protein Function
ANAPC4 has several biochemical functions, for example, protein binding,protein phosphatase binding,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANAPC4 itself. We selected most functions ANAPC4 had, and list some proteins which have the same functions with ANAPC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | ZNRF3,FBXL14B,TRAF4A,SMURF1,TRAF4B,UBE2O,CNOT4B,RNF130,FEM1B,UHRF1 |
| protein binding | FRMPD4,VAMP8,CEP170L,ZC3H14,THRB,SERTAD3,PPP2R2A,STX6,MYH7B,ZNF703 |
| protein phosphatase binding | MAP3K5,TRAF3,VCP,TRAF2,CSK,HSF4,VCAN,SHOC2,ANAPC5,JUP |
Interacting Protein
ANAPC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANAPC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANAPC4.
CDC27;BUB1B;Cdc23;Cdc16;Cdc26;CDC20
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