AMBRA1
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Official Full Name
autophagy/beclin-1 regulator 1 -
Synonyms
AMBRA1;autophagy/beclin-1 regulator 1;activating molecule in BECN1-regulated autophagy protein 1;DCAF3;DDB1 and CUL4 associated factor 3;FLJ20294;KIAA1736;WD repeat domain 94;WDR94;activating molecule in beclin-1-regulated autophagy;MGC33725
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian cells
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
AMBRA1 involved in several pathways and played different roles in them. We selected most pathways AMBRA1 participated on our site, such as Cellular responses to stress,Macroautophagy,Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMBRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Macroautophagy | MAP1LC3C,ATG101,WIPI1,WDR45,ATG4A,ATG7,AMBRA1A,UVRAG,AMBRA1B,ATG9B |
| Senescence and Autophagy | COL10A1,RSL1D1,ATG7,IFI16,MAP1LC3C,GABARAP,FKBP8,MAP1LC3B,IGFBP7,ING1 |
| Cellular responses to stress | WIPI1,WIPI2,H1F0,CDKN2C,POT1,RNF2,HIST1H1C,HDAC6,TERF1,RPS19BP1 |
Protein Function
AMBRA1 has several biochemical functions, for example, protein binding,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMBRA1 itself. We selected most functions AMBRA1 had, and list some proteins which have the same functions with AMBRA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | MC1R,YWHAE,LRPPRC,CUL2,RNF40,USP13,UBE2B,MFN2,NFKBIA,POU5F1 |
| protein binding | KLKB1,ZHX1,GCC2,JUB,HOPX,SLC38A2,TRIM6,STIM1,BMP1,VEGFAB |
Interacting Protein
AMBRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMBRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AMBRA1.
BECN1;BCL2;vif
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References
- Men, RT; Wen, MY; et al. Nogo-B: A potential indicator for hepatic cirrhosis and regulator in hepatic stellate cell activation. HEPATOLOGY RESEARCH 45:113-122(2015).
- Joseph, AM; Adhihetty, PJ; et al. Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging. PLOS ONE 8:-(2013).
