ALOXE3
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Official Full Name
arachidonate lipoxygenase 3 -
Overview
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ALOXE3;arachidonate lipoxygenase 3;epidermis-type lipoxygenase 3;E LOX;eLOX3;e LOX 3;e-LOX-3;Epidermal lipoxygenase;Lipoxygenase 3;LOXE3_HUMAN;E-LOX
Recombinant Proteins
- Human
- Rat
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALOXE3-489H | Recombinant Human ALOXE3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ALOXE3-640R | Recombinant Rat ALOXE3 Protein | Mammalian Cell | Rat | His |
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| ALOXE3-8895HCL | Recombinant Human ALOXE3 293 Cell Lysate | HEK293 | Human | Non |
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| ALOXE3-1485HF | Recombinant Full Length Human ALOXE3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 711 amino acids |
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| ALOXE3-296R | Recombinant Rat ALOXE3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ALOXE3-296R-B | Recombinant Rat ALOXE3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ALOXE3-896H | Recombinant Human ALOXE3 protein, His-tagged | E.coli | Human | His | 1-711aa |
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Involved Pathway
ALOXE3 involved in several pathways and played different roles in them. We selected most pathways ALOXE3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOXE3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ALOXE3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ALOXE3 itself. We selected most functions ALOXE3 had, and list some proteins which have the same functions with ALOXE3. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ALOXE3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOXE3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOXE3.
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