ALG5
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Official Full Name
asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae) -
Overview
This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ALG5;asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae);asparagine linked glycosylation 5 homolog (yeast, dolichyl phosphate beta glucosyltransferase);dolichyl-phosphate beta-glucosyltransferase;bA421P11.2;Alg5, S. cerevisiae, homolog of;ALG5_HUMAN;Asparagine linked glycosylation 5;Asparagine-linked glycosylation protein 5 homolog;Dolichyl phosphate beta glucosyltransferase;DolP glucosyltransferase;DolP-glucosyltransferase;OTTHUMP00000018263;dolichyl phosphate glucosyltransferase;asparagine-linked glycosylation 5 homolog (yea;RP11-421P11.2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- S.cerevisiae
- Schizosaccharomyces pombe
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
ALG5 involved in several pathways and played different roles in them. We selected most pathways ALG5 participated on our site, such as N-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| N-Glycan biosynthesis | DPM1,MAN1B1,MAN1A2,B4GALT3,MGAT1B,ALG2,MGAT2,MGAT4A,MAN1C1,ALG9 |
| Metabolic pathways | ODC1,ALDH2.1,ACAT1,GALE,HPDB,SLC27A5,IDS,UGT2B15,ME3,ATP5E |
Protein Function
ALG5 has several biochemical functions, for example, dolichyl-phosphate beta-D-mannosyltransferase activity,dolichyl-phosphate beta-glucosyltransferase activity,dolichyl-phosphate-mannose-protein mannosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG5 itself. We selected most functions ALG5 had, and list some proteins which have the same functions with ALG5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dolichyl-phosphate-mannose-protein mannosyltransferase activity | DPM1,SDF2 |
| dolichyl-phosphate beta-D-mannosyltransferase activity | DPM1 |
| oligosaccharyl transferase activity | GALNTL4,DPY19L4,POC1BL,B3GNTL1,B3GNT8,PIGB,POMGNT2,STT3B,GTDC2,DPY19L1 |
Interacting Protein
ALG5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG5.
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References
- Sponder, G; Rutschmann, K; et al. "Inside-in" or "inside-out"? The membrane topology of SLC41A1. MAGNESIUM RESEARCH 26:176-181(2013).
- Harries, E; Carmona, L; et al. Genes involved in protein glycosylation determine the activity and cell internalization of the antifungal peptide PAF26 in Saccharomyces cerevisiae. FUNGAL GENETICS AND BIOLOGY 58-59:105-115(2013).
