ALDH7A1
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Official Full Name
aldehyde dehydrogenase 7 family, member A1 -
Overview
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. -
Synonyms
ALDH7A1;aldehyde dehydrogenase 7 family, member A1;ATQ1;alpha-aminoadipic semialdehyde dehydrogenase;26g turgor protein homolog;alpha AASA dehydrogenase;alpha aminoadipic semialdehyde dehydrogenase;antiquitin 1;delta1 piperideine 6 carboxylate dehydrogenease;EPD;P6c dehydrogenase;PDE;Aldehyde dehydrogenase 7 A1;Antiquitin;antiquitin-1;OTTHUMP00000159189;OTTHUMP00000242046;alpha-AASA dehydrogenase;betaine aldehyde dehydrogenase;delta1-piperideine-6-carboxylate dehydrogenase
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ALDH7A1 involved in several pathways and played different roles in them. We selected most pathways ALDH7A1 participated on our site, such as Glycolysis / Gluconeogenesis,Ascorbate and aldarate metabolism,Fatty acid degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH7A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | GM5506,G6PC3,PGK2,PKMB,ACSS2,PGAM1B,ALDOAA,ALDOCB,ADH2-1,LDHC |
| Arginine and proline metabolism | ALDH3A2A,OAT,CNDP1,PYCR2,DAO.1,CARNS1,GATM,ALDH18A1,ALDH9A1B,GOT2A |
| Tryptophan metabolism | AANAT2,ALDH3A2,AANAT1,AANAT,ASMT,AADAT,HADHAA,MAOA,TDO2B,DHCR24 |
| Lysine degradation | DOT1L,PLOD1,GCDH,ALDH3A2,OGDHL,PIPOX,PLOD2,NSD1,ALDH9A1,HYKK.2 |
| Pyruvate metabolism | ACYP1,PDK3,ME1,ALDH9A1,GLO1,MDH1,FH,BRP44,FH1,ACSS2 |
| Lysine biosynthesis | AADAT |
| Metabolic pathways | PNAT3,IMPAD1,ASAH2,COMTB,LCT,ARG2,POLG,GLCEA,Amy1,PIK3C2B |
| Biosynthesis of amino acids | PC,MAT1A,PGAM2,pykF,SDS,CBSA,ENO2,PYCR1B,PKMB,GPT |
| Glycine, serine and threonine metabolism | PGAM1B,CBS,ALAS1,TDH,GCAT,CTH,AGXTA,AOC3,DAO.1,DAO.3 |
Protein Function
ALDH7A1 has several biochemical functions, for example, L-aminoadipate-semialdehyde dehydrogenase activity,aldehyde dehydrogenase (NAD) activity,betaine-aldehyde dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH7A1 itself. We selected most functions ALDH7A1 had, and list some proteins which have the same functions with ALDH7A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KIT,TAL2,ZBTB9,EMD,TMEM231,FERMT2,TGFB3,PMEPA1,C9orf24,IRF8 |
| aldehyde dehydrogenase (NAD) activity | ALDH1B1,ALDH1L1,ALDH2,ALDH9A1,ALDH1L2,ALDH3A2B,ALDH4A1,Aldh1a7,ALDH8A1,ALDH9A1A.1 |
Interacting Protein
ALDH7A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH7A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH7A1.
EPS8;DDA1;UBA5;RECQL5;Rc3h2;Rc3h1
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