ALDH3B2
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Official Full Name
aldehyde dehydrogenase 3 family, member B2 -
Overview
This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized. -
Synonyms
ALDH3B2;aldehyde dehydrogenase 3 family, member B2;ALDH8;aldehyde dehydrogenase family 3 member B2;acetaldehyde dehydrogenase 8;aldehyde dehydrogenase 8;OTTHUMP00000235616
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALDH3B2-448H | Recombinant Human ALDH3B2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ALDH3B2-497H | Recombinant Human Aldehyde Dehydrogenase 3 Family, Member B2, GST-tagged | E.coli | Human | GST | False |
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| ALDH3B2-59HCL | Recombinant Human ALDH3B2 cell lysate | Human | Non |
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| ALDH3B2-1408HF | Recombinant Full Length Human ALDH3B2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 385 amino acids |
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Involved Pathway
ALDH3B2 involved in several pathways and played different roles in them. We selected most pathways ALDH3B2 participated on our site, such as Glycolysis / Gluconeogenesis,Histidine metabolism,Tyrosine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH3B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phenylalanine metabolism | KEG1,PAH,HPDB,GOT2A,HPDA,AOC3,IL4I1,GOT2,GOT1,ALDH1A3 |
| Drug metabolism - cytochrome P | GSTM4,AOX3L1,UGT2A1,GSTT1B,UGT5G1,UGT1A7C,GSTAL,ALDH3A1,GSTP1,MGST1 |
| Glycolysis / Gluconeogenesis | PGAM1,ADH1B,ALDH9A1,G6PCA.2,ALDOC,LDHBA,ADH1,GM5506,HK2,ENO1 |
| Metabolic pathways | PDXKB,B3GNTL2,GKUP,MAN1C1,ADC,CERS4,KLF15,LSM1,ALDOCB,GMDS |
| Chemical carcinogenesis | GSTA5,ADH1C,UGT2B15,UGT2B7,CYP3A7-CYP3AP1,GSTT2B,MGST1,GSTA1,CYP2C70,GSTM7 |
| Tyrosine metabolism | GOT1,AOX3L1,ALDH3B1,HPD,AOX3,HPDB,MIF,ALDH3A1,TYRP1B,TH |
| Metabolism of xenobiotics by cytochrome P | MGST2,GSTM3,GSTM7,UGT1A6,GSTAL,UGT1A7,GSTA,UGT2A3,UGT1A3,MGST3 |
| Histidine metabolism | ALDH2.1,HDC,MAOB,ALDH9A1B,ALDH7A1,AMDHD1,ALDH2,ALDH1B1,ALDH2.2,AOC1 |
| beta-Alanine metabolism | UPB1,MLYCD,SRM,GAD2,ACADM,HADHAA,ALDH1A3,ALDH3A2A,GAD1B,SMOX |
Protein Function
ALDH3B2 has several biochemical functions, for example, 3-chloroallyl aldehyde dehydrogenase activity,aldehyde dehydrogenase (NAD) activity,aldehyde dehydrogenase [NAD(P)+] activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH3B2 itself. We selected most functions ALDH3B2 had, and list some proteins which have the same functions with ALDH3B2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldehyde dehydrogenase [NAD(P)+] activity | ALDH3A2B,ALDH1A3,ALDH3A1,ALDH3A2,ALDH3A2A,ALDH2,ALDH3B1 |
| 3-chloroallyl aldehyde dehydrogenase activity | ALDH9A1,ALDH1A1,ALDH3A2A,ALDH3A1,Aldh1a7,ALDH3A2B,ALDH2.1,ALDH3B1,ALDH3A2 |
| aldehyde dehydrogenase (NAD) activity | ALDH7A1,ALDH3A2,ALDH1L2,ALDH16A1,ALDH9A1A.1,ALDH9A1B,ALDH3A1,ALDH9A1,ALDH8A1,ALDH3A2A |
Interacting Protein
ALDH3B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH3B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH3B2.
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References
- Zhang, RL; Miao, Q; et al. Genome-wide DNA methylation analysis in alcohol dependence. ADDICTION BIOLOGY 18:392-403(2013).
- Holmes, RS; et al. Biochemical Genetics of Opossum Aldehyde Dehydrogenase 3: Evidence for Three ALDH3A-Like Genes and an ALDH3B-Like Gene. BIOCHEMICAL GENETICS 48:287-303(2010).
- Hartomo, TB; Pham, TVH; et al. Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1089-1098(2015).
- Holmes, RS; Hempel, J; et al. Comparative studies of vertebrate aldehyde dehydrogenase 3: Sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene. CHEMICO-BIOLOGICAL INTERACTIONS 191:113-121(2011).
