AK2
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Official Full Name
adenylate kinase 2 -
Overview
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the;reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2,;and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is;tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may;play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in;multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2. -
Synonyms
AK2;adenylate kinase 2;adenylate kinase 2, mitochondrial;ATP-AMP transphosphorylase 2;adenylate kinase isoenzyme 2, mitochondrial;ADK2;AK 2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Insect Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- E. coli
- In Vitro Cell Free System
- GST
- His
- His&GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
AK2 involved in several pathways and played different roles in them. We selected most pathways AK2 participated on our site, such as Purine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ST3GAL3B,ACADVL,MGAT5,IDH2,FUT2,IMPDH1B,NT5C1BA,GBA,CBR3,NDUFB5 |
| Purine metabolism | PKMB,PNP5B,POLR1B,NT5C3B,DCK,AK7B,PDE4C,PPAT,PDE2A,RRM2 |
Protein Function
AK2 has several biochemical functions, for example, ATP binding,adenylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AK2 itself. We selected most functions AK2 had, and list some proteins which have the same functions with AK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | RARS2,TLK2,QARS,ATP2B1,DAPK2A,HSPD1,MKNK2A,IKBKAP,IRAK2,P2RY4 |
| adenylate kinase activity | AK8,AK5,AK7,AK1,AK4 |
Interacting Protein
AK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AK2.
EIF1B;GH1;EPB41;NME2;MCC;PAK2;IKBKE;ACTR6;TRAF6;ABCC5;ABCC6;topA;VCAM1
Resources
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References
- Yan, R; Chen, MX; et al. Glycoprotein lb alpha clustering induces macrophage-mediated platelet clearance in the liver. THROMBOSIS AND HAEMOSTASIS 113:107-117(2015).
- Alibardi, L; et al. Ultrastructural immunocytochemistry for the central region of keratin associated-beta-proteins (beta-keratins) shows the epitope is constantly expressed in reptilian epidermis. TISSUE & CELL 45:241-252(2013).
