AGPAT6
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Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 6 -
Overview
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004] -
Synonyms
AGPAT6;1-acylglycerol-3-phosphate O-acyltransferase 6;LPAATZ;TSARG7;1-AGPAT 6;LPAAT-zeta;glycerol-3-phosphate acyltransferase 6;1-AGP acyltransferase 6;lysophosphatidic acid acyltransferase zeta;testis spermatogenesis apoptosis-related protein 7;1-acyl-sn-glycerol-3-phosphate acyltransferase zeta;1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- E. coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- N-GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AGPAT6-9478H | Recombinant Human AGPAT6, GST-tagged | E.coli | Human | GST | 206-456a.a. | |
| AGPAT6-1421M | Recombinant Mouse AGPAT6 Protein | Mammalian Cell | Mouse | His |
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| AGPAT6-3735Z | Recombinant Zebrafish AGPAT6 | Mammalian Cell | Zebrafish | His |
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| AGPAT6-435H | Recombinant Human AGPAT6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| AGPAT6-37HCL | Recombinant Human AGPAT6 cell lysate | Human | Non |
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| ABI1-6323H | Recombinant Human ABI1 protein, GST-tagged | E. coli | Human | N-GST | 2-304 aa |
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| AGPAT6-391M | Recombinant Mouse AGPAT6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| AGPAT6-391M-B | Recombinant Mouse AGPAT6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| AGPAT6-934HF | Recombinant Full Length Human AGPAT6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 456 amino acids |
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Involved Pathway
AGPAT6 involved in several pathways and played different roles in them. We selected most pathways AGPAT6 participated on our site, such as CDP-diacylglycerol biosynthesis,Fatty acid, triacylglycerol, and ketone body metabolism,Glycerolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CDP-diacylglycerol biosynthesis | CDS1,GPAT2,AGPAT1,AGPAT2,GK5 |
| Glycerolipid metabolism | TAE1,PNLIPRP2,AKR1A1A,Cel,LIPCA,STIL,PNLIPRP1,ALDH2.2,ALDH7A1,ALDH9A1A.1 |
| Fatty acid, triacylglycerol, and ketone body metabolism | MED20,ACOT10,ANKRD1,GRHL1,SREBF2,GLIPR1,CDK8,MED25,SLC25A20,ACAD11 |
| Metabolism | NDUFAF5,CYP4F12,DPEP2,COX14,MARCKSA,MED8,CDO1,CYP4F22,FAM96B,CYP2A7 |
| Glycerophospholipid biosynthesis | CPNE7,PLB1,PTPMT1,GPAT2,PLD4,PEMT,SLC44A5B,PITPNB,DGAT1B,CDIPT |
| Metabolic pathways | ITPKC,ETNK2,PIK3C2B,AGPAT4,GALCA,PRPS1B,PLD4,GALNT7,LASS5,TBXAS1 |
| Metabolism of lipids and lipoproteins | PTGR1,CYP27B1,ARSD,FIG4,SACM1L,CHAT,Agmo,MED9,CDIPT,ACER1 |
| Glycerophospholipid metabolism | DGKZ,CDIPT,LPIN2,PLD4,PCYT1A,AGPAT3,PLA2G3,CHPT1,LYCAT,GPD2 |
Protein Function
AGPAT6 has several biochemical functions, for example, NOT 1-acylglycerol-3-phosphate O-acyltransferase activity,glycerol-3-phosphate O-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT6 itself. We selected most functions AGPAT6 had, and list some proteins which have the same functions with AGPAT6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycerol-3-phosphate O-acyltransferase activity | GPAM,GPAT2,AGPAT9,AGPAT9L |
Interacting Protein
AGPAT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT6.
HSD17B7;1C
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References
- Bunel, A; Jorssen, EP; et al. Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential. THERIOGENOLOGY 83:228-237(2015).
- Sankella, S; Garg, A; et al. Hepatic Gluconeogenesis Is Enhanced by Phosphatidic Acid Which Remains Uninhibited by Insulin in Lipodystrophic Agpat2 Mice*. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4762-4777(2014).
