AGAP1
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Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -
Overview
This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
AGAP1;ArfGAP with GTPase domain, ankyrin repeat and PH domain 1;centaurin, gamma 2 , CENTG2;arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1;GGAP1;KIAA1099;AGAP 1;AGAP-1;AGAP1_HUMAN;Arf GAP with GTP binding proteinlike ANK repeat and PH domains 1;ArfGAP with GTPase domain ankyrin repeat and PH domain 1;Centaurin gamma 2;Centaurin-gamma-2;CENTG2;Cnt-g2;GGAP 1;GTP binding and GTPase activating protein 1;GTP-binding and GTPase-activating protein 1;MGC71657;centaurin, gamma 2;Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- E. coli
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- N-His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AGAP1-0007H | Recombinant Human AGAP1 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| AGAP1-26447TH | Recombinant Human AGAP1, His-tagged | E.coli | Human | His | 675-804 a.a. |
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| AGAP1-266R | Recombinant Rhesus monkey AGAP1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| AGAP1-536H | Recombinant Human AGAP1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| AGAP1-8984HCL | Recombinant Human AGAP1 293 Cell Lysate | HEK293 | Human | Non |
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| ABCG8-2432H | Recombinant Human ABCG8 protein, His-tagged | E. coli | Human | N-His | 21-386 aa |
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| Agap1-1550M | Recombinant Mouse Agap1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| AGAP1-2579HF | Recombinant Full Length Human AGAP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 392 amino acids |
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| AGAP1-94R | Recombinant Rhesus Macaque AGAP1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| AGAP1-94R-B | Recombinant Rhesus Macaque AGAP1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
AGAP1 involved in several pathways and played different roles in them. We selected most pathways AGAP1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | VPS29,ITCH,STAMBPB,GIT2A,EHD1B,PRKCI,ARPC1A,EHD3,RAB11FIP2,CHMP4C |
Protein Function
AGAP1 has several biochemical functions, for example, GTP binding,GTPase activator activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGAP1 itself. We selected most functions AGAP1 had, and list some proteins which have the same functions with AGAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | RASGRP3,ARHGEF6,RGS10,ARHGDIA,RGS17,AGFG1A,ADAP1,RGS19,GIT1,PREX2 |
| GTP binding | DNM1,GNL3L,RHOGA,RAP2B,DNM3A,DNM2A,DNM1L,SCG5,RAB8B,EEF2 |
| metal ion binding | GALNTL2,SNAI1A,PARN,HPX,MOB1A,ZFP354A,ARIH1L,ZNF823,VDRA,CMAH |
| phospholipid binding | PLEKHA3,NOXO1,AMPH,LC3,SEC14L2,PACSIN1,APOE,NUP35,PLA2G15,FABP1 |
Interacting Protein
AGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGAP1.
TK1;GRB7;SMN1
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References
- Yoon, HY; Jacques, K; et al. Differences between AGAP1, ASAP1 and arf GAP1 in substrate recognition: interaction with the N-terminus of Arf1. CELLULAR SIGNALLING 16:1033-1044(2004).
