AFF2
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Official Full Name
AF4/FMR2 family, member 2 -
Overview
This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation. Alternate splicing results in multiple transcript variants. -
Synonyms
AFF2;AF4/FMR2 family, member 2;FMR2, fragile X mental retardation 2;AF4/FMR2 family member 2;FRAXE;AFF2_HUMAN;FMR2;FMR2P;Fragile X E mental retardation syndrome protein;fragile X mental retardation 2;Fragile X mental retardation 2 protein;fragile X mental retardation gene associated with FRAXE;mild or borderline mental retardation;MRX2;OTTHUMP00000024204;OX19;Protein FMR-2;Protein Ox19
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AFF2-1399M | Recombinant Mouse AFF2 Protein | Mammalian Cell | Mouse | His |
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| Aff2-3231M | Recombinant Mouse Aff2, His-tagged | E.Coli or Yeast | Mouse | His | 1272 |
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| AFF2-406H | Recombinant Human AFF2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| AFF2-26444TH | Recombinant Human AFF2 | Wheat Germ | Human | Non | 111 amino acids |
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| AFF2-375M | Recombinant Mouse AFF2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| AFF2-375M-B | Recombinant Mouse AFF2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
AFF2 involved in several pathways and played different roles in them. We selected most pathways AFF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
AFF2 has several biochemical functions, for example, G-quadruplex RNA binding,RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF2 itself. We selected most functions AFF2 had, and list some proteins which have the same functions with AFF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-quadruplex RNA binding | FXR1,PATL2,DHX36 |
| RNA binding | WRAP53,IFIT8,IREB2,RPL7,DPPA5,RCAN3,RPL13,SAMHD1,SF3A1,PATL2 |
Interacting Protein
AFF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF2.
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