ADH5
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- Overview
- Review / Q&A
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Official Full Name
alcohol dehydrogenase 5 (class III), chi polypeptide -
Overview
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. -
Synonyms
ADH5;alcohol dehydrogenase 5 (class III), chi polypeptide;FDH, formaldehyde dehydrogenase;alcohol dehydrogenase class-3;ADH 3;ADHX;Alcohol dehydrogenase (class III) chi polypeptide;alcohol dehydrogenase 5 (class III) chi polypeptide;Alcohol dehydrogenase class 3;Alcohol dehydrogenase class chi chain;Alcohol dehydrogenase class III;class III alcohol dehydrogenase 5 chi subunit;FDH;formaldehyde dehydrogenase;Glutathione dependent formaldehyde dehydrogenase;hydroxymethyllutathione dehydrogenase;OTTHUMP00000219913;alcohol dehydrogenase class-III;S-(hydroxymethyl)glutathione dehydrogenase;glutathione-dependent formaldehyde dehydrogenase;alcohol dehydroge;ADH-3;FALDH;GSNOR;GSH-FDH
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- Yeast
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
ADH5 involved in several pathways and played different roles in them. We selected most pathways ADH5 participated on our site, such as Biological oxidations,Biosynthesis of antibiotics,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ethanol oxidation | ADH1A,ADH1C,ADH7,ADH6,ADH4,ADH8B,ADH8A,ADH1B |
| Degradation of aromatic compounds | RGN,AKR1A1,AKR1A1A,AKR1A1B |
| Biological oxidations | ADH6,CYP3A7,UGT1B5,CYP2AD6,PAOX,SULT1C4,SULT1ST6,AADAC,CYP1B1,CYP2W1 |
| Drug metabolism - cytochrome P450 | CYP2A6,CYP3A5,CYP2C9,ADH4,ADH6,GSTK1,CYP2C8,ADH2-2,ADH7,CYP2D6 |
| Fatty acid degradation | ALDH9A1,ACSL4B,ADH2-2,ACSL1,ADH1,CYP4A11,ACSL3,ADH7,ECI1,ALDH3A2A |
| Chemical carcinogenesis | MGST1,CYP2C50,CYP2C8,ADH2-1,CYP2C55,HSD11B1,CYP2C18,GSTK1,UGT1A6,CYP1A1 |
| Carbon metabolism | GAPDH,IDH1,FBP1B,ALDH6A1,TPI1A,MUT,PRPS2,ACSS2L,GLDC,PGK2 |
| Biosynthesis of antibiotics | NME6,DLST,GPR19,ANI_1_2390104,pykF,BPNT1,CTH,AGXT,LDHAL6B,SDSL |
Protein Function
ADH5 has several biochemical functions, for example, S-(hydroxymethyl)glutathione dehydrogenase activity,alcohol dehydrogenase (NAD) activity,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH5 itself. We selected most functions ADH5 had, and list some proteins which have the same functions with ADH5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fatty acid binding | FABP1,PTGDS,FABP2,HNF4A,LBFABP,FABP7A,FABP10A,ACOX2,NDUFAB1,FABP5 |
| protein homodimerization activity | MLL1,SYT10,APOBEC3G,MTPAP,C6orf108,CIDEA,RASGRP1,C1QB,BCL11A,MYH7 |
| zinc ion binding | MMP25,LHX2A,SUPT4H1,PCGF5,NR1D2A,MDM2,TRAF2,LIMK1,LMX1BB,ZDHHC1 |
| alcohol dehydrogenase (NAD) activity | DHRS9,ADH7,ADH8B,ADH6,ADH1A,ADH1,ADH8A,ADH1C,ADH4 |
| electron carrier activity | IVD,XDH,GLRX,NCF2,ASPH,HSD17B6,GSR,AKR7A2,ACOX1,IDH3B |
| formaldehyde dehydrogenase activity | ADH8B |
Interacting Protein
ADH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH5.
VTN;ESRRA;ARNT;CSNK2B;PRDX1;CHD3;PQLC1;HDAC1
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