ADCK3
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Official Full Name
aarF domain containing kinase 3 -
Overview
This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. -
Synonyms
ADCK3;aarF domain containing kinase 3;CABC1, chaperone, ABC1 activity of bc1 complex homolog (S. pombe) , chaperone, ABC1 activity of bc1 complex like (S. pombe) , chaperone ABC1 (activity of bc1 complex, S.pombe) like;chaperone activity of bc1 complex-like, mitochondrial;coenzyme Q8 homolog (yeast);COQ8;SCAR9;aarF domain containing protein kinase 3;ADCK 3;CABC 1;Chaperone ABC1 (activity of bc1 complex S.pombe) like;Chaperone ABC1 activity of bc1 complex homolog;Chaperone ABC1 like;Chaperone activity of bc1 complex like;Chaperone activity of bc1 complex like mitochondrial;Coenzyme Q8 homolog;COQ 8;MGC4849;OTTHUMP00000035734;OTTHUMP00000035735;OTTHUMP00000035736;OTTHUMP00000035737;OTTHUMP00000038685;aarF domain-containing protein kinase 3;chaperone, ABC1 activity of bc1 complex homolo;ARCA2;CABC1
Recombinant Proteins
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- Human
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- His
- GST
- His&Fc&Avi
Involved Pathway
ADCK3 involved in several pathways and played different roles in them. We selected most pathways ADCK3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ADCK3 has several biochemical functions, for example, ADP binding,ATP binding,kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCK3 itself. We selected most functions ADCK3 had, and list some proteins which have the same functions with ADCK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ADP binding | MYO3A,MYH9,MYH10,ME1,LONP1,ACTA1,PRKAG2,GCLC,GLUD2,MYO6 |
| ATP binding | TEX14,ACTB,P2RX5,P2RX3,WEE1,PHKG2,STK4,MKNK2A,STK33,MAP4K4 |
| kinase activity | STK24B,BMPR1AA,CAMK1GB,Fert2,SPS2,TNIKB,INSRA,EK1,KITA,HIPK2 |
| protein binding | E2F2,PRKAB2,EPB41B,FGFR2,FAM120B,UNC13A,GH1,SNRPB,C14orf104,NAA10 |
Interacting Protein
ADCK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCK3.
RABAC1;AGTRAP;TMEM239;TMEM159;REEP6
Resources
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References
- Desbats, MA; Lunardi, G; et al. Genetic bases and clinical manifestations of coenzyme Q(10) (CoQ(10)) deficiency. JOURNAL OF INHERITED METABOLIC DISEASE 38:145-156(2015).
- Stefely, JA; Reidenbach, AG; et al. Mitochondrial ADCK3 Employs an Atypical Protein Kinase-like Fold to Enable Coenzyme Q Biosynthesis. MOLECULAR CELL 57:83-94(2015).
