ADAMTS4
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 4 -
Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008] -
Synonyms
ADAMTS4;ADAM metallopeptidase with thrombospondin type 1 motif, 4;ADMP-1;ADAMTS-2;ADAMTS-4;A disintegrin and metalloproteinase with thrombospondin motifs 4;ADAM-TS4;ADAM-TS 4;aggrecanase-1;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- CHO
- Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ADAMTS4 involved in several pathways and played different roles in them. We selected most pathways ADAMTS4 participated on our site, such as Degradation of the extracellular matrix,Endochondral Ossification,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endochondral Ossification | RUNX2A,MMP13,SERPINH1,FRZB,MGP,ADAMTS5,DDR2,NKX3.2,IFT88,PTHLHA |
| Post-translational protein modification | ALG2,DPH2,CBX8,THSD1,SENP1,CTAGE5,SPON1B,PHC3,ADAMTS3,NEU4 |
| O-glycosylation of TSR domain-containing proteins | SPON1,ADAMTS5,ADAMTSL4,THSD1,ADAMTS15,ADAMTSL1,SPON1A,ADAMTS3,B3GALTL,ADAMTS8 |
| Degradation of the extracellular matrix | CTSB,COL23A1,LOC100686744,CTSL2,ADAMTS18,FAM49BA,MMP17,TLL2,EMID2,CTRB1 |
| Extracellular matrix organization | COL6A2,MATN4,CRTAP,COL3A1,COL8A2,ELANE,CTS7,ITGB3A,ADAMTS3,COL16A1 |
| Metabolism of proteins | MBOAT4,TRAPPC9,MUC1,EID3,LMCD1,SMC6,TIMM22,ST6GAL2B,GZMH,TRAPPC2 |
| O-linked glycosylation | ADAMTSL4,MUC1,B3GALTL,ST6GALNAC2,B3GNT8,SPON2,MUC5AC,MUC15,SPON1A,ADAMTSL3 |
Protein Function
ADAMTS4 has several biochemical functions, for example, metalloendopeptidase activity,metallopeptidase activity,peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS4 itself. We selected most functions ADAMTS4 had, and list some proteins which have the same functions with ADAMTS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KCTD6,SEPT11,HIST1H4E,IL12A,DMKN,INSIG2,CT45A3,DAG1,FKBP5,HMOX1 |
| protease binding | A2M,RNF139,Serpina1c,PYCARD,TNF,ITGA3,TP53,MBP,BDKRB2,SERPINB4 |
| metalloendopeptidase activity | PAPPA,ADAM10B,MMP14A,BMP1B,ADAMTS1,MMP7,MMP24,ADAMTS2,NLN,ADAMTS7 |
| metallopeptidase activity | ADAM8A,HE2,ECEL1,ENPEP,AGBL4,LNPEP,ADAM10,STAMBPL1,BRCC3,PSMD14 |
| peptidase activity | LGMN,PCSK5B,SPCS3,CAPN1B,FURINA,PM20D1.1,Adamts19,F9B,CTS7,CASPB |
| zinc ion binding | PJA2,MARCH10,THAP11,KAT7A,FNTB,KMT2E,MARCH6,CAD,THRAA,NR1H2 |
Interacting Protein
ADAMTS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS4.
ZBTB16;YTHDC1
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References
- Valenzuela, JC; Heise, C; et al. Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 369:-(2014).
- Wainwright, SD; Bondeson, J; et al. ADAMTS-4_v1 Is a Splice Variant of ADAMTS-4 That Is Expressed as a Protein in Human Synovium and Cleaves Aggrecan at the Interglobular Domain. ARTHRITIS AND RHEUMATISM 65:2866-2875(2013).
