ADAMTS10
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 10 -
Overview
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008] -
Synonyms
ADAMTS10;ADAM metallopeptidase with thrombospondin type 1 motif, 10;WMS;WMS1;ADAM-TS10;ADAMTS-10;A disintegrin and metalloproteinase with thrombospondin motifs 10;ADAM-TS 10;zinc metalloendopeptidase;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Zebrafish
- Mammalian Cells
- E.coli
- E.Coli/Yeast
- HEK293
- His
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
ADAMTS10 involved in several pathways and played different roles in them. We selected most pathways ADAMTS10 participated on our site, such as Metabolism of proteins,O-glycosylation of TSR domain-containing proteins,O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Post-translational protein modification | DPH5,TRAPPC9,SENP5,ADAMTS5,MUC1,TRAPPC2L,BET1,ADAMTS15,EID3,DOHH |
| Metabolism of proteins | ACE,ADAMTSL1,IGFBP5A,SERP1,PCSK2,SFTPC,YIF1A,CHCHD4,FURINB,MUC20 |
| O-linked glycosylation | ADAMTS20,KCNA6,ADAMTS18,GALNTL2,MUCL1,MUC13,SSPO,ADAMTS1,MUC15,THSD1 |
| O-glycosylation of TSR domain-containing proteins | ADAMTS13,ADAMTS20,C8orf84,SSPO,ADAMTS5,ADAMTS18,THSD7A,ADAMTS3,ADAMTS4,ADAMTSL5 |
Protein Function
ADAMTS10 has several biochemical functions, for example, metalloendopeptidase activity,molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS10 itself. We selected most functions ADAMTS10 had, and list some proteins which have the same functions with ADAMTS10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | ZNF34,TRIM105,ZNF330,EDEM3,ZNRF1,P2RX1,PMPCB,HDAC6,PAPLNB,POLR2L |
| molecular_function | ILDR1A,CAR6,NHSL1,TDPOZ4,DDX19A,SUN5,TTLL5,ARL6IP5,IER5L,TBC1D2B |
| metalloendopeptidase activity | THOP1,ADAMTS5,BMP1A,ADAM28,ADAMTS13,YBEY,ADAMTS9,ADAM5P,ADAM2,MMP14B |
| protein binding | APEH,RAB5B,GBAS,C3orf52,XAB2,TRAPPC6B,RWDD3,BOK,AGTR1,ZNF10 |
Interacting Protein
ADAMTS10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS10.
TK1;ANXA7;HMGCL;CDKN1A;SMN1;PCYT2;LAMTOR3
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