ADAM22
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Official Full Name
ADAM metallopeptidase domain 22 -
Overview
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants. -
Synonyms
ADAM22;ADAM metallopeptidase domain 22;a disintegrin and metalloproteinase domain 22;disintegrin and metalloproteinase domain-containing protein 22;MDC2;metalloproteinase like;disintegrin like;and cysteine rich protein 2;and cysteine-rich protein 2;disintegrin-like;ADA22_HUMAN;ADAM 22;MDC 2;Metalloproteinase disintegrin ADAM22 3;Metalloproteinase like disintegrin like and cysteine rich protein 2;Metalloproteinase-disintegrin ADAM22-3;Metalloproteinase-like;MGC149832;OTTHUMP00000174585;OTTHUMP00000174587;OTTHUMP00000174588;OTTHUMP00000207170;OTTHUMP00000207298;metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
Recombinant Proteins
- Human
- Mouse
- Chicken
- Xenopus laevis
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
ADAM22 involved in several pathways and played different roles in them. We selected most pathways ADAM22 participated on our site, such as Developmental Biology,LGI-ADAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | GFRA4,SCN4A,COL9A3,AP2M1,COL9A1A,EFNA1A,NRP2,CLTA,GDNF,GFRA1 |
| LGI-ADAM interactions | LGI4,STX1B,LGI2B,LGI3,LGI2A,LGI1,ADAM23,CACNG2B,LGI2,LGI1B |
Protein Function
ADAM22 has several biochemical functions, for example, integrin binding,metalloendopeptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM22 itself. We selected most functions ADAM22 had, and list some proteins which have the same functions with ADAM22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TRIM105,UQCRC1,TEX13A,ZNF205,PTGR1,SKI,CA12,S100A7,MT1E,EP300 |
| protein binding | FAM64A,UBE2I,NRG4,FDXR,SIKE1,SPN,F3,GDNF,TCEA1,CLPB |
| metalloendopeptidase activity | UQCRC2,FAP,NRD1B,MMP16,ADAMDEC1,MMP20,PITRM1,MIPEP,MMP17,PAPPAA |
| integrin binding | THBS1,ICAM2,ICAM1,FN1A,CYR61,NF2,ADAMTS5,FERMT3,CIB2,THBS4 |
Interacting Protein
ADAM22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM22 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM22.
YWHAZ;MYB;RAC2;EPS8;CSNK1E
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