ACTA1
-
Official Full Name
actin, alpha 1, skeletal muscle -
Overview
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. -
Synonyms
ACTA1;actin, alpha 1, skeletal muscle;ACTA;actin, alpha skeletal muscle;alpha-actin-1;alpha skeletal muscle actin;ASMA;CFTD;MPFD;NEM1;NEM2;NEM3;CFTD1;CFTDM
Recombinant Proteins
- Human
- Mouse
- Chicken
- Bovine
- Rat
- Rabbit
- Porcine
- E.coli
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- Rat Serum
- Pigeon Serum
- Insect cells
- Rabbit skeletal muscle
- Porcine skeletal muscle
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ACTA1-305H | Recombinant Human ACTA1 protein, His-tagged | E.coli | Human | His | 1-377 aa | |
| ACTA1-306H | Recombinant Human ACTA1 protein, GST-tagged | E.coli | Human | GST | 1-377 aa | |
| ACTA1-1238M | Recombinant Mouse ACTA1 Protein | Mammalian Cell | Mouse | His |
|
|
| ACTA1-125H | Recombinant Human ACTA1 protein, GST-tagged | Wheat Germ | Human | GST | 1-377 a.a. |
|
| ACTA1-2743C | Recombinant Chicken ACTA1 | Mammalian Cell | Chicken | His |
|
|
| ACTA1-3090B | Recombinant Bovine ACTA1, His-tagged | E.Coli or Yeast | Bovine | His | 377 |
|
| Acta1-3091R | Recombinant Rat Acta1, His-tagged | E.Coli or Yeast | Rat | His | 377 |
|
| ACTA1-477R | Recombinant Rat ACTA1 Protein | Mammalian Cell | Rat | His |
|
|
| ACTA1-7HCL | Recombinant Human ACTA1 lysate | HEK293 | Human | Non |
|
|
| ACTA1-133R | Recombinant Rat ACTA1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| ACTA1-133R-B | Recombinant Rat ACTA1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| ACTA1-157R | Native Rabbit skeletal muscle alpha Actin | Rat Serum | Rabbit | Non | Full length native Rabbit skeletal muscle alpha Actin |
|
| Acta1-158M | Native Mouse skeletal muscle alpha Actin | Pigeon Serum | Mouse | Non | Full length native mouse skeletal muscle alpha Actin |
|
| ACTA1-281M | Recombinant Mouse ACTA1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| ACTA1-281M-B | Recombinant Mouse ACTA1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| ACTA1-304H | Recombinant Human ACTA1 Protein (3-377 aa), His-tagged | E.coli | Human | His | 3-377 aa |
|
| ACTA1-564H | Recombinant Human ACTA1 protein, His-tagged | Insect cells | Human | His | 3-377aa |
|
| ACTA1-853R | Native Rabbit ACTA1 Protein | Rabbit skeletal muscle | Rabbit | Non | 375 amino acids |
|
| ACTA1-854P | Native Porcine ACTA1 Protein | Porcine skeletal muscle | Porcine | Non | 375 amino acids |
|
Involved Pathway
ACTA1 involved in several pathways and played different roles in them. We selected most pathways ACTA1 participated on our site, such as Caspase cascade in apoptosis,Hypothetical Network for Drug Addiction,Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RhoA signaling pathway | DIAPH1,CYR61,MKL1 |
| Signaling events mediated by focal adhesion kinase | KLF8,BMX,ARHGAP26,ARHGEF28 |
| Caspase cascade in apoptosis | CASP2,NUMA1,TFAP2A,PARP1,SATB1,CASP4,CFL2,LMNB1,DFFA,GAS2 |
| Hypothetical Network for Drug Addiction | TERF2IP,ACTA1B,CX28.8,NISCH,GJB7,ZHX2 |
| Striated Muscle Contraction | TNNI2A.3,MYBPC2,DESMB,CMLC1,TCAP,SMYHC3,DES,MYLZ3,SMYHC2,MYBPC1 |
| Myometrial Relaxation and Contraction Pathways | RAMP1,PKIG,ATF5,RGS10,CRHR1,IGFBP4,IGFBP6,CNN1,CRCP,RGS19 |
Protein Function
ACTA1 has several biochemical functions, for example, ADP binding,ATP binding,myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTA1 itself. We selected most functions ACTA1 had, and list some proteins which have the same functions with ACTA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ADP binding | MYO18A,PRPS1,MYO6,ABCG1,PRKAG2,MIEF1,PRKAG1,VCP,HSP104,CHORDC1 |
| structural constituent of cytoskeleton | SYNM,TUBA2,TUBA4L,NEFL,ARPC1B,TUBAL3,TUBA8L2,TUBG1,TUBA1A,ARPC5 |
| ATP binding | RFC4,DDX3Y,TLK1A,PI4KB,SEPHS2,CKMT1A,NLRP12,IP6K2,UBE2KB,ATP2A1L |
| protein binding | DSC2,EFTUD2,RTDR1,USP25,LAPTM4B,TRAPPC6B,DUSP19,RBM26,PGR,EIF2B4 |
| myosin binding | FXYD1,VAMP2,GIPC1,SMYD1B,DMD,SLC6A4,VETZ,KIRREL,CALD1B,RHOA |
Interacting Protein
ACTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTA1.
HTRA2;DNASE1;GC;GSN;ssh-2;Kcnma1;SSH3;SSH1;ZNF16;TNNI3K;TRIM63;RNF167;SMURF2;CD247;ARRB1;BTK;LRRK2;TRAF3IP1;LRCH3
Resources
Related Services
Related Products
References
- Schreckenbach, T; Schroder, JM; et al. Novel TPM3 mutation in a family with cap myopathy and review of the literature. NEUROMUSCULAR DISORDERS 24:117-124(2014).
- Nakagawa, Y; Inoue, H; et al. Molecular biological analysis of cardiac effect of high temperature in rats. LEGAL MEDICINE 14:63-68(2012).
