ACSL4
-
Official Full Name
acyl-CoA synthetase long-chain family member 4 -
Overview
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. -
Synonyms
ACSL4;acyl-CoA synthetase long-chain family member 4;FACL4, fatty acid Coenzyme A ligase, long chain 4 , mental retardation, X linked 63 , mental retardation, X linked 68 , MRX63, MRX68;long-chain-fatty-acid--CoA ligase 4;long chain fatty acid Coen
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- Mamanlian cells
- In Vitro Cell Free System
- E. coli
- E.coli expression system
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
- N-His
Involved Pathway
ACSL4 involved in several pathways and played different roles in them. We selected most pathways ACSL4 participated on our site, such as Fatty acid biosynthesis,Fatty acid degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | PEX19,CRAT,ACSL1A,CAT,ACOX3,PEX13,ACSL5,BAAT,MLYCD,NOS2B |
| Adipocytokine signaling pathway | TNF,CHUK,G6PC,PPARA,RXRBA,IKBKB,PRKAA2,NFKBIE,NFKBIAA,AKT2 |
| Fatty acid degradation | ALDH2,ACOX1,CYP4A11,GCDHB,ACADSB,ALDH7A1,ACSBG2,ECI1,ADH1,EHHADH |
| Fatty acid metabolism | HADH,ACADL,EHHADH,ACSL4B,ACADS,ACADM,ACSL4A,ACAA1A,SCD5,PECR |
| Metabolic pathways | ACSM5,CYP21A2,PLA2G1B,OGDHL,CTH,PLA2G2E,PNAT10,PLA2G6,UQCRQ,CYP2S1 |
| PPAR signaling pathway | PPARDB,SLC27A2,SCP2,FABP6,ACSL4B,ANGPTL4,ACSL1B,FABP7A,ACSL1A,PCK2 |
| Fatty Acid Biosynthesis | ACACA,ACACB,ACSL4A,ACSL3,ACSL1,ECHDC2,ACSL3A,OXSM,ACSBG2,ACSL4B |
Protein Function
ACSL4 has several biochemical functions, for example, ATP binding,arachidonate-CoA ligase activity,long-chain fatty acid-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL4 itself. We selected most functions ACSL4 had, and list some proteins which have the same functions with ACSL4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| very long-chain fatty acid-CoA ligase activity | SLC27A5,SLC27A4,SLC27A2,ACSBG1,SLC27A3,SLC27A1B,SLC27A1A |
| ATP binding | EIF4A2,EHD2,AURKA,Acsm2a,PSMC1A,PRKCG,DGKG,GRK5,RPS6KA3,ZAK |
| long-chain fatty acid-CoA ligase activity | SLC27A4,ACSBG2,SLC27A5,ACSL1,SLC27A2,ACSBG1,ACSL5,SLC27A3,SLC27A1A,ACSL3 |
Interacting Protein
ACSL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL4.
YWHAZ;DSE;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;ACSL3;1C;ABCG1;MRPS15;SLC1A5;TJAP1;SPG20;EDEM1;BRF1;UVRAG;p27958-pro_0000037575;TMEM173
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References
- Tuohetahuntila, M; Spee, B; et al. Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1851:220-230(2015).
- Xu, WD; Yang, XY; et al. Up-regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: A comparative proteomic study. JOURNAL OF PROTEOMICS 113:57-72(2015).
