ACOT7
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Official Full Name
acyl-CoA thioesterase 7 -
Overview
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. -
Synonyms
ACOT7;acyl-CoA thioesterase 7;cytosolic acyl coenzyme A thioester hydrolase;ACH1;ACT;BACH;brain acyl CoA hydrolase;CTE II;hBACH;LACH1;MGC1126;CTE-IIa;acyl-CoA thioesterase 2;brain acyl-CoA hydrolase;acyl-CoA thioesterase, long chain;long ch
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ACOT7 involved in several pathways and played different roles in them. We selected most pathways ACOT7 participated on our site, such as Biosynthesis of unsaturated fatty acids,Fatty Acyl-CoA Biosynthesis,Fatty acid elongation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOT7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | EPM2A,GC,ADSSL1,INSIG2,MED26,GCKR,CPT2,ACOT11A,CEPT1,CYP2K6 |
| Biosynthesis of unsaturated fatty acids | SCD5,HADHA,ACAA1A,Scd2,TECR,ACOT5,HADHAA,ACAA1,PTPLAD2,TECRB |
| Metabolism of lipids and lipoproteins | AKR1C2,FA2H,Alb,APOEA,CYP11B1,ABHD3,PTGR1,ARSH,NFYBB,CYP4B1 |
| Triglyceride Biosynthesis | ACOT11A,Agmo,DGAT1B,ACOT12,ACOT9.2,ACOT11B,TMEM195,ELOVL1A,ACOT6,ACOT9 |
| Fatty acid, triacylglycerol, and ketone body metabolism | ACAD11,MMAA,MED7,G0S2,GLIPR1,Agmo,ACOT10,CTGF,AGPAT6,SIN3B |
| Fatty acid elongation | ACOT2,ELOVL2,ELOVL7B,HSD17B12A,ELOVL6,ELOVL7A,PTPLA,ELOVL4A,PPT2,PTPLAD1 |
| Fatty Acyl-CoA Biosynthesis | ACSF3,ACOT9,SLC25A1,SLC25A1A,ACOT10,ACOT12,ACOT9.1,ACOT11,ELOVL1A,ACOT13 |
Protein Function
ACOT7 has several biochemical functions, for example, carboxylic ester hydrolase activity,fatty-acyl-CoA binding,long-chain fatty acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOT7 itself. We selected most functions ACOT7 had, and list some proteins which have the same functions with ACOT7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| palmitoyl-CoA hydrolase activity | ACOT1,ACOT2,ACOT5,PPT1,ACOT8,BAAT,THEM4,GNPAT,THEM5 |
| carboxylic ester hydrolase activity | ABHD4,NCEH1A,CES1,ACOT8,FAM135A,LYPLA2,Aadacl3,ACOT9,ACOT5,ABHD2B |
| long-chain fatty acyl-CoA binding | SCP2,DBI |
| protein homodimerization activity | PDCD10,GSTA4,DPY30,ZFP652,CADM1A,SDCBP2,CSF1,OSTA,MAP3K9,USH2A |
| fatty-acyl-CoA binding | ACAD8,ACOX1,ACBD4,ALDH6A1,ACBD6,ACADL,ACOX2,ACBD7,ACBD5A,SOAT1 |
| protein binding | CDC25B,RFPL3,NINJ1,LBH,TRPV5,ATP6V0A4,PSMD9,GPRASP2,PCGF3,MED24 |
Interacting Protein
ACOT7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOT7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOT7.
MAGEA6;CAMK2B;THAP1;UBQLN1;UBQLN1;HEL-S-101;ATXN1;TERF1
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