ACK
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Official Full Name
CG14992 gene product from transcript CG14992-RA -
Overview
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and;GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence;of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the;GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction;pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length;nature of only two transcript variants has been determined. -
Synonyms
NK2;tyrosine kinase, non-receptor, 2;ACK;ACK1;FLJ44758;FLJ45547;p21cdc42Hs;activated p21cdc42Hs kinase;activated Cdc42-associated kinase 1;EC 2.7.10.2;TNK2;tyrosine kinase, non-receptor, 2;Nefa;Calnuc;AI607786
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ACK-234H | Recombinant Human Tyrosine Kinase, Non-receptor, 2, GST-tagged, Active | Sf9 Cells | Human | GST | 110-476 a.a. |
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Involved Pathway
ACK involved in several pathways and played different roles in them. We selected most pathways ACK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ACK has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ACK itself. We selected most functions ACK had, and list some proteins which have the same functions with ACK. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ACK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACK here. Most of them are supplied by our site. Hope this information will be useful for your research of ACK.
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