ACCN4
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Official Full Name
amiloride-sensitive cation channel 4, pituitary -
Overview
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. Alternative splicing at this locus results in two transcript variants encoding different isoforms. -
Synonyms
ACCN4;amiloride-sensitive cation channel 4, pituitary;amiloride-sensitive cation channel 4;ASIC4;BNAC4;pituitary;ACCN4_HUMAN;Acid sensing ion channel 4;Acid-sensing ion channel 4;Amiloride sensitive cation channel 4;Brain sodium channel 4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ACCN4-1177M | Recombinant Mouse ACCN4 Protein | Mammalian Cells | Mouse | His |
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| ACCN4-247M | Recombinant Mouse ACCN4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ACCN4-247M-B | Recombinant Mouse ACCN4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Accn4-30M | Recombinant Mouse Accn4 Protein, His-tagged | E.coli | Mouse | His | Pro372-Cys539 |
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Involved Pathway
ACCN4 involved in several pathways and played different roles in them. We selected most pathways ACCN4 participated on our site, such as Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACCN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory mediator regulation of TRP channels | Adcy4,PRKCD,CYP2C37,TRPA1,ITPR3,CAMK2A,CYP2C39,PRKCB,CALM4,CYP2C70 |
Protein Function
ACCN4 has several biochemical functions, for example, sodium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACCN4 itself. We selected most functions ACCN4 had, and list some proteins which have the same functions with ACCN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium channel activity | ASIC1B,SCN8AB,PKD2L1,SLC4A11,TRPM5,SCN4AA,ACCN3,ASIC3,TRPM2,ASIC4A |
Interacting Protein
ACCN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACCN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACCN4.
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References
- Sasaki, K; Matsuo, M; et al. Febrile Seizures: Characterization of Double-Stranded RNA-Induced Gene Expression. PEDIATRIC NEUROLOGY 41:114-118(2009).
- Dhingra, A; Sulaiman, P; et al. Probing neurochemical structure and function of retinal ON bipolar cells with a transgenic mouse. JOURNAL OF COMPARATIVE NEUROLOGY 510:484-496(2008).
