ACAT1
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Official Full Name
acetyl-CoA acetyltransferase 1 -
Overview
This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. -
Synonyms
ACAT1;acetyl-CoA acetyltransferase 1;ACAT, acetyl Coenzyme A acetyltransferase 1;acetyl-CoA acetyltransferase, mitochondrial;acetoacetyl Coenzyme A thiolase;THIL;acetoacetyl-CoA thiolase;acetyl-Coenzyme A acetyltransferase 1;mitochondrial acetoac
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Cynomolgus
- Human
- Rat
- Chicken
- Mouse
- Mammalian Cell
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- His
- His&T7
- His&Fc&Avi
- Non
- GST
Involved Pathway
ACAT1 involved in several pathways and played different roles in them. We selected most pathways ACAT1 participated on our site, such as Fatty acid degradation,Synthesis and degradation of ketone bodies,Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Propanoate metabolism | MCEE,HADHA,LDHBB,LDHBA,LDHAL6B,HADHAB,MLYCD,SUCLA2,ACACA,LDHAL6A |
| Butanoate metabolism | OXCT2B,ACSM3,L2HGDH,EHHADH,GAD1,HADHAA,OXCT2A,HADH,ACSM5,AACS |
| Synthesis and degradation of ketone bodies | HMGCL,OXCT1A,OXCT2B,ACAT2,HMGCS1,OXCT1B,BDH2,BDH1,OXCT2A,OXCT2 |
| Metabolic pathways | ALOX15B,TPI1A,GPT,PCYT1AA,AMT,NDST3,ADH7,GPAA1,ATP6V1C1,B4GALNT1 |
| Valine, leucine and isoleucine degradation | ACAA2,MCCC2,HMGCL,ALDH9A1A.1,IVD,HMGCS1,HMGCS2,BCKDHB,BCAT2,ACAA1A |
| Pyruvate metabolism | ALDH9A1A.1,ME2,LDHBA,GRHPRB,ALDH2,GRHPRA,ACSS2,LDHD,ALDH7A1,PDK2 |
| Glyoxylate and dicarboxylate metabolism | GLULB,ACAT2,HAO1,GCSH,ACO2,AGXT,PGP,MDH1,GLULA,AGXTB |
| Lysine degradation | TMLHE,ALDH2,BBOX1,SETD8B,SUV420H1,SUV39H2,SETDB1,GCDHA,SUV39H1A,SETD7 |
| Fatty acid degradation | ALDH2.2,ACSL1A,ACSL5,ADH2-2,GCDH,ACSL4A,CPT1A,ALDH2.1,ACSBG2,ACSL4B |
Protein Function
ACAT1 has several biochemical functions, for example, acetyl-CoA C-acetyltransferase activity,coenzyme binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAT1 itself. We selected most functions ACAT1 had, and list some proteins which have the same functions with ACAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| coenzyme binding | WWOX,HMGCRA,HMGCRB,GCH1,ATAT1,QDPRB1,GCLC,HMGCR,TDH2,TSTA3 |
| protein homodimerization activity | SLC4A1,TBX1,CCBL1,NOS1,XPNPEP1,TBX15,PVALB,GRHPR,NAGA,CADM2A |
| metal ion binding | RPP21,HMGCLL1,LIAS,KEL,OVOL2,ZBTB7C,ADCY7,LATS2,ESYT1,STK25 |
| acetyl-CoA C-acetyltransferase activity | ACAA1A,HADHA,ACAT2 |
| enzyme binding | BLZF1,KDM4C,HINFP,LAMP2,BIRC5,SIRT1,USP22,RAD9A,SLC18A1,RFC5 |
Interacting Protein
ACAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAT1.
VCAM1;EIF1B;GH1;MCC;MPG;HLA-B;HLA-C;TNIK;AGXT;GABARAPL2;SIRT4
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References
- Chang, HT; Olson, LK; et al. Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication for ketogenic diet therapy. NUTRITION & METABOLISM 10:-(2013).
- Yang, Y; Wang, YF; et al. Specific Kv1.3 blockade modulates key cholesterol-metabolism-associated molecules in human macrophages exposed to ox-LDL. JOURNAL OF LIPID RESEARCH 54:34-43(2013).
