ABCB4
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Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 4 -
Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).This protein is a member of the MDR/TAP subfamily.Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation.This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate.The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile.Alternative splicing of this gene results in several products of undetermined function. -
Synonyms
ABCB4;ATP-binding cassette, sub-family B (MDR/TAP), member 4;MDR3, PGY3;multidrug resistance protein 3;GBD1;MDR2;PFIC 3;P-glycoprotein 3;multiple drug resistance 3;ATP-binding cassette sub-family B member 4;P glycoprotein 3/multiple drug resistance 3;P-glycoprotein-3/multiple drug resistance-3;MDR3;PGY3;ABC21;MDR2/3;PFIC-3
Recombinant Proteins
- Mouse
- Rat
- Zebrafish
- Human
- Dictyostelium Discoideum
- Mammalian Cell
- E.coli
- HEK293
- E.coli expression system
- His
- His&T7
- His&Fc&Avi
- GST
Involved Pathway
ABCB4 involved in several pathways and played different roles in them. We selected most pathways ABCB4 participated on our site, such as ABC transporters,Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | AQP4,ABCG2,SLC27A5,SLC9A3,SCARB1,SLC51A,Adcy4,FXYD2,ABCB1A,SLC10A1 |
| ABC transporters | ABCB10,ABCC3,ABCC5,ABCC12,ABCA1B,ABCB3L1,ABCC10,ABCD1,ABCC6,ABCA3 |
Protein Function
ABCB4 has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCB4 itself. We selected most functions ABCB4 had, and list some proteins which have the same functions with ABCB4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity | DYNC1H1,PSMC3,CLPB,KIF27,OLA1,CHD1L,KIF20A,ABCD3B,HSPA5,SMARCA4A |
| xenobiotic-transporting ATPase activity | ABCB1,ABCG2,ABCB1A,Abcb1b |
| phosphatidylcholine transporter activity | PITPNBL,PCTP,PITPNA |
| nucleotide binding | PPARGC1A,GMPPAA,NMRK2,RBM39B,ABCD3A,ATP13A,MYH4,RBM38,SEPT8A,IGF2BP2A |
| ATP binding | KIF5AA,HELZ2,CAMK1DA,HIPK3,KIAA1804,LIMK1,PSMC2,ABCG2C,NTRK1,PIP4K2B |
| ATPase activity, coupled to transmembrane movement of substances | ABCA6,ABCC12,ABCA5,ABCD3,ABCA4A,ABCG8,ABCG5,ABCG3,DPY19L2,ABCB3L1 |
| hydrolase activity | PSMC1B,ENTPD2A.1,INPP5J,PSMB9B,GPN3,NUDT6,ABCB1A,ALP3,CAPN8,TMPRSS11F |
Interacting Protein
ABCB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCB4.
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References
- Yoshida, S; Ikenaga, N; et al. Extrahepatic Platelet-Derived Growth Factor-beta, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice. GASTROENTEROLOGY 147:1378-1392(2014).
- Hirschfield, GM; Chapman, RW; et al. REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. GASTROENTEROLOGY 144:1357-1374(2013).
