AASS

  • Official Full Name

    aminoadipate-semialdehyde synthase

  • Overview

    This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia.

  • Synonyms

    AASS;aminoadipate-semialdehyde synthase;alpha-aminoadipic semialdehyde synthase, mitochondrial;LKRSDH;LORSDH;lysine-2-oxoglutarate reductase;aminoadipic semialdehyde synthase;alpha-aminoadipate semialdehyde synthase;lysine-ketoglutarate reductase

Recombinant Proteins

  • Human
  • Rat
  • Bovine
  • Zebrafish
  • Mouse
  • E.coli
  • E.Coli/Yeast
  • Mammalian Cells
  • HEK293
  • His
  • His&T7
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ALG14-9574H Recombinant Human ALG14 protein, His-tagged E.coli Human His 27-216 aa
Aass-3339R Recombinant Rat Aass, His-tagged E.Coli/Yeast Rat His 926
AASS-3340B Recombinant Bovine AASS, His-tagged E.Coli/Yeast Bovine His 926
AASS-390R Recombinant Rat AASS Protein Mammalian Cells Rat His
AASS-7710Z Recombinant Zebrafish AASS Mammalian Cells Zebrafish His
Aass-8112M Recombinant Mouse Aass protein, His & T7-tagged E.coli Mouse His&T7 Met477~Leu926
AASS-0180H Recombinant Human AASS Protein (Val33-Leu455), N-His-tagged E.coli Human His Val33-Leu455
AASS-45R Recombinant Rat AASS Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
AASS-45R-B Recombinant Rat AASS Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    AASS involved in several pathways and played different roles in them. We selected most pathways AASS participated on our site, such as Adherens junction,Amoebiasis,Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with AASS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) SGCD,SGCB,SGCG,DAG1,CDH2,ITGA1,CACNG1,CACNG4,ACTB,RYR2
    Amoebiasis CD1D,LAMB3,LAMB1,CD1d1,GM-CSF,ADCY1,GNA15,FN1,RELA,TGFB2
    Adherens junction MAPK1,PARD3,VCL,ACTN3B,WASF3B,TGFBR1A,CDC42,PVRL3,WAS,SNAI1
    Platelet degranulation PLEK,F13A1A.1,CD9A,TFA,IGF2B,BRPF3,CD9B,CALU,MMRN1,WDR1
    Hemostasis HBBE1.1,NFE2,CD177,TFA,KIF26A,S100A10B,MAFGA,F9B,CFHL2,ZFPM2A
    Focal adhesion VAV2,VAV1,ARHGAP5,ITGA6B,FYNB,PIK3R2,FLT1,FLNB,PIK3R3A,VEGFAB
    Leukocyte transendothelial migration CLDN6,CLDN2,ACTN4,CLDN17,PIK3R2,VAV2,CLDN8,CLDN5,MAPK12,CLDN3
    Platelet activation, signaling and aggregation CLEC1B,CD9B,RHOGA,ABHD12,CAP1,SERPINF2B,F13A1B,TFA,SPARC,F13A1A.1

    Protein Function

    AASS has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,actin filament binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AASS itself. We selected most functions AASS had, and list some proteins which have the same functions with AASS. You can find most of the proteins on our site.

    Function Related Protein
    actin filament binding DBNLA,MYH3,GAS7,WIPF1A,TNNC1,PPP1R9A,MYH11A,TRPV4,SVILA,WIPF2B
    ligand-dependent nuclear receptor transcription coactivator activity ACTN1,CALCOCO1,SLC30A9,ACTN4,NCOA3,MED30,KDM1A,BUD31,DCAF6,PUS1
    calcium ion binding CHP1,SYT3,CGREF1,GUCA1B,PLCD1A,DLB,GRIN1,EPDR1,FAT1A,CDH3
    RNA polymerase II regulatory region sequence-specific DNA binding ONECUT3,BHLHA15,NHLH2,ALX1,AEBP1,ARID3A,TFAP2C,GFI1AA,NFIL3,ETV5
    nucleoside binding CDA,PNP,POLA1,ACTN4
    retinoic acid receptor binding MED25,PRAMEF10,HMGA1-RS1,RXRA,PRAME,HMGA1,NSD1,CTBP2,SNW1,PRAMEF6
    poly(A) RNA binding DQX1,TNRC6B,RPS15A,HNRNPDL,SECISBP2,MRPS28,RBM38,TBL2,MSI2,C2orf15
    chromatin DNA binding VAX2,VAX1,HDAC3,THRA,RELA,PER1,PRDM14,THRB,GRHL3,HIST1H1E
    ion channel binding EPN1,SCN5A,PHPT1,PACS1A,SLC8A1,RNF207,HOMER1,SUMO1,S100A10,ACTN4

    Interacting Protein

    AASS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AASS here. Most of them are supplied by our site. Hope this information will be useful for your research of AASS.

    Resources

    References

    • Gatrell, SK; Berg, LE; et al. Tissue distribution of indices of lysine catabolism in growing swine. JOURNAL OF ANIMAL SCIENCE 91:238-247(2013).

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