AARS
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Official Full Name
alanyl-tRNA synthetase -
Overview
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. -
Synonyms
AARS;alanyl-tRNA synthetase;alanine--tRNA ligase, cytoplasmic;alanine tRNA ligase 1;cytoplasmic;alaRS;renal carcinoma antigen NY-REN-42;alanine tRNA ligase 1, cytoplasmic;alanyl-tRNA synthetase, cytoplasmic;CMT2N
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Zebrafish
- Sf9 Cells
- E.coli
- Mammalian Cells
- Insect Cells
- E.Coli/Yeast
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AARS-51H |
Recombinant Human Alanyl-tRNA Synthetase, His-tagged
|
Sf9 Cells | Human | His | ||
| AARS-9196H | Recombinant Human AARS, GST-tagged | E.coli | Human | GST | 1-350a.a. | |
| AARS-1271C | Recombinant Chicken AARS | Mammalian Cells | Chicken | His |
|
|
| Aars-2487M | Recombinant Mouse Aars protein(Met1-Asn968), His-tagged | Insect Cells | Mouse | His | Met1-Asn968 |
|
| Aars-3250R | Recombinant Rat Aars, His-tagged | E.Coli/Yeast | Rat | His | 968 |
|
| AARS-3856Z | Recombinant Zebrafish AARS | Mammalian Cells | Zebrafish | His |
|
|
| AARS-386R | Recombinant Rat AARS Protein | Mammalian Cells | Rat | His |
|
|
| AARS-521MCL | Recombinant Mouse AARS cell lysate | Insect Cells | Mouse | Non |
|
|
| Aars-1455M | Recombinant Mouse Aars Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
|
|
| AARS-241H | Recombinant Human AARS Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| AARS-41R | Recombinant Rat AARS Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
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| AARS-41R-B | Recombinant Rat AARS Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
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| AARS-459H | Recombinant Human AARS Protein (Met1-Asn968), His-tagged | Insect Cells | Human | His | Met1-Asn968 |
|
| AARS-757HF | Recombinant Full Length Human AARS Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 968 amino acids |
|
| WNT3A-1698H | Recombinant Human WNT3A protein, His-tagged | E.coli | Human | His | 19-120 aa |
|
Involved Pathway
AARS involved in several pathways and played different roles in them. We selected most pathways AARS participated on our site, such as Aminoacyl-tRNA biosynthesis,Cytosolic tRNA aminoacylation,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with AARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytosolic tRNA aminoacylation | MADD,KARS,FARSB,AIMP1,EEF1E1,AIMP2,DARS |
| Aminoacyl-tRNA biosynthesis | GATC,HARS2,VARS,FARSB,PSTK,FARS2,VARS2,QARS,TARSL2,PARS2 |
| tRNA Aminoacylation | EARS2,AIMP2,KARS,MADD,FARSB,FARS2,DARS,EEF1E1,WARS2,AIMP1 |
| Gene Expression | Txn1,PTRF,PAPOLA,EIF2S1A,TRIM28,LSM6,KRBOX4,PUS7,ZCRB1,ZNF614 |
Protein Function
AARS has several biochemical functions, for example, ATP binding,alanine-tRNA ligase activity,amino acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AARS itself. We selected most functions AARS had, and list some proteins which have the same functions with AARS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tRNA binding | XPO5,TRMT1,TERT,SSB,FDXACB1,EEF1A1,ALKBH8,THG1L,TRMT1L,RARS |
| metal ion binding | DGKQ,PPP1CA,ATP1A1A.1,PRDM5,AGFG1A,ANGPT2,NPEPPS,GYG1,ACLYA,STAMBPL1 |
| ATP binding | NLRP5,ZNF143B,ATP1A1,UBE2D2,EGFRA,ILF2,MYO3B,INO80,EHD1,HSPA6 |
| alanine-tRNA ligase activity | AARS2,AARSD1 |
| amino acid binding | ASS1,DPYS,AARS2,DDAH1,AGXT,TH,SHMT2,DDAH2,TAT,GCHFR |
| aminoacyl-tRNA editing activity | DTD2,DTD1,PRORSD1,IARS,IARS2,LARS,LARS2,VARS2,VARS |
Interacting Protein
AARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AARS here. Most of them are supplied by our site. Hope this information will be useful for your research of AARS.
VCAM1;ETS1;YWHAZ;15-deoxy-delta(12,14;ere_dna;FN1;HSP90AB1;Calml3
Resources
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References
- Zimmerman, ES; Heibeck, TH; et al. Production of Site-Specific Antibody-Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System. BIOCONJUGATE CHEMISTRY 25:351-361(2014).
- Gono, T; Kawaguchi, Y; et al. Brief Report Association of HLA-DRB1*0101/*0405 with susceptibility to anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis in the Japanese population. ARTHRITIS AND RHEUMATISM 64:3736-3740(2012).
