| Description : |
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. |
| Source : |
Baculovirus |
| Species : |
Human |
| Tag : |
His |
| Form : |
Liquid |
| Bio-activity : |
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 range ≤1.5ng/ml. |
| Molecular Mass : |
14.2 kDa |
| Protein length : |
124aa |
| Endotoxin : |
< 1 EU per 1ug of protein (determined by LAL method) |
| Purity : |
> 90% by SDS-PAGE |
| Applications : |
SDS-PAGE, Bioactivity |
| Storage : |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles. |
| Concentration : |
0.5mg/ml (determined by absorbance at 280nm) |
| Storage Buffer : |
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
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