Creative Biomart Blog

Fri, 2025/03/14

Scientists Discover Key Mechanism by Which A Β Promotes Tau Protein Diffusion

Recently, Nicolai Franzmeier's team from the Stroke and Dementia Research Institute at the University of Munich in Germany published an important research result. They found that the overactivity and enhanced functional connectivity of neurons induced by Aβ pathology are key factors in promoting the spread of tau pathology. Specifically, the study first found that Aβ deposition enhances the functional connectivity between the pathological initiation core area of tau (lower temporal lobe) and the pathological susceptibility brain areas of tau (such as parietal and occipital lobes). Su

Fri, 2025/03/14

New research paves the way for immunotherapy for childhood cancer

In a new study, researchers from Karolinska Institute and Astrid Lindgren Children's Hospital have determined how children's immune systems respond to different types of cancer based on age. This discovery reveals significant differences in immune responses between children and adults, and may provide new tailored treatment options for children with cancer. The relevant research results were published online in the Cell journal, with the paper titled “Systems-level immunomonitoring in children with solid tumors to enable precision medicine”. “The activation of the immune syst

Fri, 2025/03/14

Discovery of short IL-18 and revelation of its anti-tumor mechanism

Meng Guangxun's team from the Chinese Academy of Sciences Shanghai Institute of Immunology and Infection cooperated with Liu Chenying's team from the Xinhua Hospital affiliated to the School of Medicine of Shanghai Jiaotong University, and published a research paper entitled “Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth” in the journal Nature Immunology. This study found that short IL-18 produced by caspase-3 cleavage exerts inhibitory effects on tumor growth by mobilizing NK cells. Our Related Products In this new study, the research tea

Thu, 2025/03/13

ABCC1 Turns into a Key 'Barrier' For Cancer Cells to Resist PROTAC Therapy

This study used genetic screening to determine that ABCC1 is the main PROTAC resistance factor in cancer cells. It limits therapeutic efficacy by excreting MZ1 hydrolysis products and has different effects on multiple PROTACs in different cancer cell lines. Other related resistance and susceptibility factors were also discovered. In the field of cancer treatment, protein hydrolysis targeted chimeras (PROTACs) are gradually emerging as a new generation of drugs. This type of drug can accurately target and degrade proteins closely related to cancer growth, bringing hope to overcome "untreatable"

Mon, 2025/01/20

The Fatal Signal of Pancreatic Cancer! How Does The Dose Of KRAS Mutation Determine The Fate Of Patients?

Pancreatic cancer is the third leading cause of cancer-related death worldwide. Its five-year survival rate is as low as 10%. It is a malignant tumor with an extremely poor prognosis. Pancreatic ductal adenocarcinoma (PDAC) is the most common histological type of pancreatic cancer, accounting for the vast majority of all cases. Research has found that over 90% of PDAC patients have KRAS gene activation mutations (KRAS mutations), which are not only closely related to tumor formation and progression, but have also long been considered an “undruggable” target. Although

Mon, 2025/01/20

Scientists Have Discovered a New Method to Starve Prostate Cancer Tumors at the Cellular Level

Cancer can trigger multiple pathways to slow down external and internal stress, thereby continuing its growth and progression. Previous studies have reported that eIF2 kinase GCN2 and integrated stress response have certain constitutive activity in prostate cancer and require maintenance of the amino acid homeostasis required to promote tumor growth. However, although the loss of GCN2 function reduces the availability of intracellular amino acids and the growth of prostate cancer, there is no significant cell death. Recently, a research report titled “Coordination b

Mon, 2025/01/20

Chinese and American Scientists Collaborate To Develop a Protein Based Artificial Neural Network

In a new study, researchers from Westlake University in China and the California Institute of Technology in the United States designed a protein-based system in living cells that can process multiple signals and make decisions based on these signals. The relevant research results were published in the Science journal, with the title “A synthetic protein-level neural network in mammalian cells”. They also introduced a unique term “perceptein”, which is a combination of protein and perceptron. Perceptron is a fundamental artificial neural network concept that effectively s

Mon, 2025/01/20

How Does Steatohepatitis Develop Into Liver Cancer

Researchers from the University of California have published a research paper titled “FBP1 controls liver cancer evolution from senescent MASH hepatocyte” in the journal Nature. The study resolved the contradiction between the state of aging cells and liver cancer, revealing the key role of FBP1 in regulating liver cell aging and HCC development, as well as the interaction between FBP1 and p53 and NRF2. The results indicate that the loss of FBP1 promotes tumorigenesis through AKT activation, while the re-expression of FBP1 can inhibit the development of HCC. Th