Creative Biomart Blog

Endometriosis is a common disease affecting approximately 190 million women of childbearing age, characterized by ectopic growth of tissue similar to the endometrium outside the uterine cavity, leading to severe chronic pain, infertility, and menstrual flow abnormalities. This disease has attracted much attention due to its significant impact on quality of life, but compared to other diseases with similar effects, research investment is seriously insufficient. This lack of investment has…

Brown adipose tissue (BAT) plays an important role in mammalian energy metabolism, especially in cold environments, as it helps maintain body temperature through non-shivering thermogenesis. The thermogenesis process of BAT is activated by norepinephrine and relies on uncoupling protein 1 (UCP1) on the inner membrane of mitochondria. By consuming the electrochemical proton gradient within the mitochondria, energy is converted into heat, thereby achieving thermogenesis function. In addition, BAT can also…

Cancer cells excrete metabolic byproducts such as lactate into the surrounding tumor microenvironment during their growth process. Recently, researchers at the University of Pittsburgh found that these lactic acids can cause T cells (an important immune cell) to lose their anti-cancer ability. When T cells run out of energy and become functionally depleted, they take up these lactic acids, further weakening their combat effectiveness. However, when researchers blocked the protein…

Planned exercise can lower blood pressure, which has been widely recognized. However, researchers have paid relatively little attention to the impact of casual exercise in daily life.   Recently, a research report titled “Device-Measured 24-Hour Movement Behaviors and Blood Pressure: A 6-Part Compositional Individual Participant Data Analysis in the ProPASS Consortium” was published in the journal Circulation. Scientists from University College London and other institutions found that adding a small…

Since the first deciphering of the genetic code in the 1960s, our genes have been like an open book, containing a blueprint for life that has become increasingly clear to scientists. By analyzing the base sequences on chromosomes, we can identify genes and understand how genetic variations affect health status. This fundamental law of life applies universally to all living organisms, from the smallest bacteria to complex humans.   However,…

Living systems rely on buffering mechanisms to maintain their robustness to genetic and environmental disturbances, a phenomenon known as “canalization”. One of the buffering mechanisms is the protein folding chaperone heat shock protein 90 (Hsp90), which can buffer disturbances during protein folding. Hsp90 can stabilize a series of proteins with direct adaptive functions; Reduce the impact of harmful mutations and allow them to accumulate in a latent state within the…

This is one of the main findings of a new study led by researchers at the Sloan Kettering Cancer Center (MSK): TGF – β and RAS signaling pathways jointly promote the spread of lung adenocarcinoma, which is the leading cause of cancer death worldwide. Their research results in animal models indicate that removing one of these two signals prevents lung cancer from spreading (metastasizing) to new parts of the body….

When accidentally touch the hot wok handle, a sharp and alert signal immediately emanates from your fingertips, racing through the spinal cord and reaching the brainstem. Here, a team of specialized neurons take over the baton and transmit this pain information to a key area deep in the brain – the amygdala. This is the command center for emotional reactions, which will trigger your fear of heat and make you…