Creative Biomart Blog

Sun, 2024/01/21

Research Progress on the Interaction Mechanism between Bunyavirus and Host

Recently, the team of Wang Hualin, Deng Fei, and Ning Yunjia from the Chinese Academy of Sciences Wuhan Virology Research Institute/National Viral Resource Bank published the research papers titled "Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins" and "Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity". The above research elucidates new interaction mechanisms between the virus and host cells of two highly pathogenic Bunyaviruses, CCHFV and SFTSV, expanding our underst

Tue, 2024/01/02

The Reasons for The Therapeutic Effect of CTLA-4 Inhibitors Being Sluggish

As the "predecessors" in immune checkpoint inhibitors, the development of anti-CTLA-4 monoclonal antibodies in recent years has not been ideal. From the perspective of approved indications, their single-drug treatment uses are few and can only be paired with PD-1/L1 inhibitors. If we look at the failure cases of clinical research, it will be even more heart-wrenching. So the question is, what is blocking the anti-CTLA-4 monoclonal antibody? The research findings just published by the Rockefeller University team in Cancer Immunology Research provide an explanation: the inhibitory IgG recepto

Tue, 2024/01/02

Protein IKAROS Regulates the Development of B Cells

The nucleus is a busy place. Cellular proteins twist and pull DNA, folding the genome into complex three-dimensional structures that support the function of its coding regions. This arrangement is crucial for cell development, but the specific steps for different types of cells vary greatly. Establishing correct communication between genes and distant control switches in the right cells at the right time is not an easy task. In fact, few proteins have the correct functional combination to organize the genome into the correct structure. In a new study, researchers from the La Jolla Institute

Tue, 2024/01/02

New Research Has Found Biomarkers for Predicting the Risk of Human Cell Aging and Death

As cells age, they experience aging, a state where they stop growing but continue to release inflammatory and tissue-degrading molecules. When a person is young, the immune system will respond by eliminating aging cells, commonly known as "zombie cells". However, zombie cells will continue to exist and lead to a series of age-related health problems and diseases. In a new study, researchers from the Mayo Clinic in the United States analyzed zombie cells and explained aging at the cellular level. They thus revealed the biological characteristics of aging cells. The relevant research results

Tue, 2024/01/02

MSL2 Ensures the Expression Mechanism of Mammalian Biallelic Genes

Have you ever thought about why every chromosome in our cells has two copies? During the breeding process, we obtain a copy from each of our parents. This means that we also obtained two copies or alleles of each gene from each chromosome or pair of parents. Both alleles can produce messenger ribonucleic acid (mRNA), which is the formula required for mRNA to manufacture proteins and maintain cell operation. Scientists assume that each gene has two alleles, which are redundant systems built into cells. If a mutation occurs in an allele on one of the chromosomes or causes a decrease in mRNA p

Mon, 2023/12/04

Themis2 Can Regulate Natural Killer Cell Immune Memory

Immune memory is a hallmark of the adaptive immune system in the body. Although natural killer cells (NK cells) are essential innate immune cells for the host's immediate defense system, they can also differentiate into memory NK cells. Currently, researchers have not fully elucidated the molecular mechanisms behind controlling this differentiation process. Recently, a research report titled “Themis2 regulates natural killer cell memory function and formation” was published in the journal Nature Communications. Scientists from institutions such as the University of Tsukuba in Japan identified

Mon, 2023/12/04

The Regulation of Cancer Stem Cells and Its Implications for Targeted Cancer Therapy

Tumor occurrence and progression are considered to be a complex progressive process involving multi-level reactions and accumulation of mutations. In the past few decades, there have been many studies on this topic in the field of oncology. These studies mainly focus on tumor cells, tumor microenvironment, tumor heterogeneity, etc., among which tumor heterogeneity is closely related to the occurrence and malignancy of tumors. Cancer stem cells (CSCs), as one of the theories explaining the mechanism of tumor heterogeneity, have received widespread attention. Recently, researchers from Sichua

Mon, 2023/12/04

Molecular Mechanism behind MAF Protein Promoting Breast Cancer Metastasis

Breast cancer is the most common type of cancer among women. There are more than 2 million new cases of breast cancer every year. The survival rate of patients is very high, about 90%, when the tumor is still limited to breast tissue; however, when cancer cells spread beyond breast tissue and begin to form metastases in other organs, it significantly worsens the patient's prognosis and poses great challenges to their treatment. In previous studies, researchers believed that MAF protein was directly related to the increased risk of breast cancer metastasis, but the reason behind the association