Creative Biomart Blog

Fri, 2024/12/20

A New Class of Antiviral Drugs May Help Prevent Future COVID-19 Epidemics

Paxlovid was launched in December 2021. As an effective antiviral drug, it is an effective antiviral drug. But like many antiviral drugs before it, scientists know that at some point, paroxetine may lose some efficacy due to resistance. Now, researchers dedicated to addressing such emerging threats have identified a novel approach for treating SARS-CoV-2 infection in a new study. They conducted a conceptual validation of a new class of antiviral drugs that not only target SARS, but also many RNA viruses, including Ebola virus and dengue virus. In addition, they can also

Fri, 2024/12/20

From Random Search to Precise Activation: A New Mechanism for Translation Initiation

Gene expression is the core mechanism for maintaining life activities, and translation initiation is an important link in it. The efficiency and accuracy of the translation initiation process directly affect protein synthesis, which is crucial for the normal function of cells. In eukaryotes, most mRNA molecules rely on the 7-methylguanosine cap (mRNA cap) located at the 5′ end to initiate translation. However, the specific molecular mechanism of this critical step has long been a hot and difficult topic in research. Previous studies have shown that a trimeric complex cal

Fri, 2024/12/20

Protein MED12 Plays a Crucial Role in Coordinating T-cell Rest and Activation

Cells in the immune system do not always fight. They often rest and wait for threats such as viruses or bacteria. When these threats arise, these cells activate to protect the body. The delicate balance between rest and activation is crucial for human health—immune cells must be prepared to activate to resist threats, but if they become too active, it may lead to autoimmune diseases. But what controls this important balance? In a new study, researchers from institutions such as the Gladstone Institute and the University of California, San Francisco focused on T cells, wh

Fri, 2024/12/20

Clearing Aging Cells Expressing P21 to Promote Skin Wound Healing

Extending lifespan by eliminating aging inflammatory cells is a tempting idea, but scientists in the field of anti-aging suspect that it is too simplistic. Now, in a new study, researchers from the University of Connecticut have confirmed that as age increases, inflammatory cells become diverse, some of which play important roles in the body. The relevant research results were published online in the journal Nature Aging, with the title “Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing”. Our Related Proteins Scientists

Fri, 2024/11/15

Can Blocking Lactate Restart Anti-Cancer T Cells?

Cancer cells excrete metabolic byproducts such as lactate into the surrounding tumor microenvironment during their growth process. Recently, researchers at the University of Pittsburgh found that these lactic acids can cause T cells (an important immune cell) to lose their anti-cancer ability. When T cells run out of energy and become functionally depleted, they take up these lactic acids, further weakening their combat effectiveness. However, when researchers blocked the protein that inputs lactate into cells, these exhausted T cells surprisingly regained their vitality, i

Fri, 2024/11/15

Small Exercises Can Greatly Reduce Blood Pressure-With Just an Additional 5 Minutes of Exercise per Day, Blood Pressure Can Be Significantly Improved

Planned exercise can lower blood pressure, which has been widely recognized. However, researchers have paid relatively little attention to the impact of casual exercise in daily life. Recently, a research report titled “Device-Measured 24-Hour Movement Behaviors and Blood Pressure: A 6-Part Compositional Individual Participant Data Analysis in the ProPASS Consortium” was published in the journal Circulation. Scientists from University College London and other institutions found that adding a small amount of exercise in daily life, such as climbing stairs or cycling, can

Fri, 2024/11/15

Why Has The Pain Treatment Of Endometriosis Been Stagnant? Can New Research Bring Breakthroughs?

Endometriosis is a common disease affecting approximately 190 million women of childbearing age, characterized by ectopic growth of tissue similar to the endometrium outside the uterine cavity, leading to severe chronic pain, infertility, and menstrual flow abnormalities. This disease has attracted much attention due to its significant impact on quality of life, but compared to other diseases with similar effects, research investment is seriously insufficient. This lack of investment has led to significant challenges in both basic research and the development of new treatme

Fri, 2024/11/15

New Mechanism of ACLY Regulating Thermogenesis and Metabolic Stress in Brown Adipose Tissue

Brown adipose tissue (BAT) plays an important role in mammalian energy metabolism, especially in cold environments, as it helps maintain body temperature through non-shivering thermogenesis. The thermogenesis process of BAT is activated by norepinephrine and relies on uncoupling protein 1 (UCP1) on the inner membrane of mitochondria. By consuming the electrochemical proton gradient within the mitochondria, energy is converted into heat, thereby achieving thermogenesis function. In addition, BAT can also help prevent cardiovascular metabolic diseases and certain types of