Creative Biomart Blog

Tue, 2024/03/19

The Influence of Age and Number of Mutations on the Size of Clonal Hematopoiesis

Hainan Medical College's Ren Ruibao, Cai Wangwei, and Shanghai Jiao Tong University's Chen Zhu jointly published a research paper on PNAS titled "The impact of age and number of mutations on the size of clonal hematopoiesis", which reported an in-depth analysis of Clonal Hematopoiesis (CH) in the elderly population with longevity (age ≥ 90 years old) and general health (age 60-89 years old). This study utilized targeted deep sequencing and found that the occurrence and development of CH are closely related to the expression of age and aging biomarkers. The incidence of CH in the elderly gro

Tue, 2024/03/19

Genetic Anxiety Switch in the Body

Recently, a research report titled "An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behavior in mice and humans" was published in the journal Molecular Psychology. Scientists from institutions such as the University of Aberdeen found through their research that special DNA regions in the human genome may play an important role in controlling anxiety disorders in the body, this key gene may affect the anxiety level of the mouse body. According to data from the Mental Health Foundation, after the COVID-19 pandemic, the proportion of

Tue, 2024/02/20

TRIB3-TRIM8 Complex Regulates HNF4Α Stability to Promote the Progression of Non-Alcoholic Fatty Liver Disease

Hepatocellular endoplasmic reticulum stress plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Hepatonuclear factor 4 α (HNF4α) reduced expression is an important event in the pathogenesis of non-alcoholic fatty liver and other liver diseases. Does endoplasmic reticulum stress regulate the expression of HNF4α is not clear yet. The purpose of this study is to elucidate the mechanism of HNF4 α protein degradation and exploration of treatment strategies protecting HNF4α stability during the progression of non-alcoholic fatty liver disease. Recently, resea

Tue, 2024/02/20

Potential Therapeutic Targets for Human Inflammatory Bowel Disease and Colitis Induced Colorectal Cancer

Intestinal inflammation can trigger a vicious cycle that disrupts the sensitive relationships between food, digestive acids, microorganisms, and the immune system, further promoting inflammation and sometimes even leading to tumor growth; Recently, a research report published in the journal JCI Insight titled "Farnesoid X receptor mediates macrophage-intrinsic responses to suppress colitis-induced colon cancer progression," scientists from institutions such as the University of Wisconsin Madison identified a promising new target for developing new therapies through their research, It may poten

Tue, 2024/02/20

The Mechanism by Which Leukemia Stem Cells Promote Their Own Growth after Chemotherapy

The mystery of why myeloid leukemia begins to grow again after chemotherapy kills most malignant cells and how to prevent growth through reused drugs may be solved through new research. The bone marrow of patients with acute myeloid leukemia (AML) contains a rare group of leukemia stem cells (LSCs) that do not grow and therefore are not killed by chemotherapy. However, after treatment, these cells began to grow and produce AML cells, but it is currently unclear what initiated this process. In a new study, researchers from the University of Birmingham, Newcastle University, and Princess M

Tue, 2024/02/20

How HIV Capsid Enters the Nuclear Pore Barrier Pathway

In a new study, Dr. David Jacques, a medical researcher at the University of New South Wales in Australia, and his team discovered how the human immunodeficiency virus (HIV) breaks through the nucleus to establish infection, a discovery that goes beyond the scope of HIV biology. The relevant research results were published online in the journal Nature, with the title "The HIV capsid mimics karyopherin engagement of FG-nucleoporins". To infect cells, HIV must enter the target cell and reach the nucleus located at the center of the cell, where it produces enough copies of the genetic code to

Sun, 2024/02/18

The Special Protective Effects of Breast Milk

Breastfeeding can provide significant health benefits for newborns and infants by providing nutrition, immune protection, and shaping the gut microbiota. Although scientists have long believed that breast milk contains complement components, the physiological correlation of complement components in breast milk is not clear to them. Recently, a research report titled "Complement in breast milk modifies offspring gut microbiota to promote infant health " was published in the journal Cell. Scientists from institutions such as Johns Hopkins University found through their research that immune compo

Sun, 2024/02/18

Reveal A New Immune Pathway for The Treatment of Bone Metastasis in Breast Cancer

Immunotherapy is a very promising method for the treatment of metastatic breast cancer, which can provide new possibilities for treatment. Although checkpoint inhibitors show some hope in the treatment of metastatic breast cancer, their therapeutic effect on patients with bone metastases is disappointing. The lack of such efficacy seems to have a certain specificity for the bone environment, which will show the characteristics of avoiding inhibition. Recently, a research report titled "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis" was publish