Creative Biomart Blog

Thu, 2025/03/13

ABCC1 Turns into a Key 'Barrier' For Cancer Cells to Resist PROTAC Therapy

This study used genetic screening to determine that ABCC1 is the main PROTAC resistance factor in cancer cells. It limits therapeutic efficacy by excreting MZ1 hydrolysis products and has different effects on multiple PROTACs in different cancer cell lines. Other related resistance and susceptibility factors were also discovered. In the field of cancer treatment, protein hydrolysis targeted chimeras (PROTACs) are gradually emerging as a new generation of drugs. This type of drug can accurately target and degrade proteins closely related to cancer growth, bringing hope to overcome "untreatable"

Mon, 2025/01/20

The Fatal Signal of Pancreatic Cancer! How Does The Dose Of KRAS Mutation Determine The Fate Of Patients?

Pancreatic cancer is the third leading cause of cancer-related death worldwide. Its five-year survival rate is as low as 10%. It is a malignant tumor with an extremely poor prognosis. Pancreatic ductal adenocarcinoma (PDAC) is the most common histological type of pancreatic cancer, accounting for the vast majority of all cases. Research has found that over 90% of PDAC patients have KRAS gene activation mutations (KRAS mutations), which are not only closely related to tumor formation and progression, but have also long been considered an “undruggable” target. Although

Mon, 2025/01/20

Scientists Have Discovered a New Method to Starve Prostate Cancer Tumors at the Cellular Level

Cancer can trigger multiple pathways to slow down external and internal stress, thereby continuing its growth and progression. Previous studies have reported that eIF2 kinase GCN2 and integrated stress response have certain constitutive activity in prostate cancer and require maintenance of the amino acid homeostasis required to promote tumor growth. However, although the loss of GCN2 function reduces the availability of intracellular amino acids and the growth of prostate cancer, there is no significant cell death. Recently, a research report titled “Coordination b

Mon, 2025/01/20

Chinese and American Scientists Collaborate To Develop a Protein Based Artificial Neural Network

In a new study, researchers from Westlake University in China and the California Institute of Technology in the United States designed a protein-based system in living cells that can process multiple signals and make decisions based on these signals. The relevant research results were published in the Science journal, with the title “A synthetic protein-level neural network in mammalian cells”. They also introduced a unique term “perceptein”, which is a combination of protein and perceptron. Perceptron is a fundamental artificial neural network concept that effectively s

Mon, 2025/01/20

How Does Steatohepatitis Develop Into Liver Cancer

Researchers from the University of California have published a research paper titled “FBP1 controls liver cancer evolution from senescent MASH hepatocyte” in the journal Nature. The study resolved the contradiction between the state of aging cells and liver cancer, revealing the key role of FBP1 in regulating liver cell aging and HCC development, as well as the interaction between FBP1 and p53 and NRF2. The results indicate that the loss of FBP1 promotes tumorigenesis through AKT activation, while the re-expression of FBP1 can inhibit the development of HCC. Th

Fri, 2024/12/20

A New Class of Antiviral Drugs May Help Prevent Future COVID-19 Epidemics

Paxlovid was launched in December 2021. As an effective antiviral drug, it is an effective antiviral drug. But like many antiviral drugs before it, scientists know that at some point, paroxetine may lose some efficacy due to resistance. Now, researchers dedicated to addressing such emerging threats have identified a novel approach for treating SARS-CoV-2 infection in a new study. They conducted a conceptual validation of a new class of antiviral drugs that not only target SARS, but also many RNA viruses, including Ebola virus and dengue virus. In addition, they can also

Fri, 2024/12/20

From Random Search to Precise Activation: A New Mechanism for Translation Initiation

Gene expression is the core mechanism for maintaining life activities, and translation initiation is an important link in it. The efficiency and accuracy of the translation initiation process directly affect protein synthesis, which is crucial for the normal function of cells. In eukaryotes, most mRNA molecules rely on the 7-methylguanosine cap (mRNA cap) located at the 5′ end to initiate translation. However, the specific molecular mechanism of this critical step has long been a hot and difficult topic in research. Previous studies have shown that a trimeric complex cal

Fri, 2024/12/20

Protein MED12 Plays a Crucial Role in Coordinating T-cell Rest and Activation

Cells in the immune system do not always fight. They often rest and wait for threats such as viruses or bacteria. When these threats arise, these cells activate to protect the body. The delicate balance between rest and activation is crucial for human health—immune cells must be prepared to activate to resist threats, but if they become too active, it may lead to autoimmune diseases. But what controls this important balance? In a new study, researchers from institutions such as the Gladstone Institute and the University of California, San Francisco focused on T cells, wh