Creative Biomart Blog

Wed, 2024/10/16

FOXP3 Regulation: The Unique Molecular Mechanisms behind the Occurrence of Multiple Sclerosis and Other Autoimmune Diseases

More than 20 years ago, researchers at Yale University discovered a special type of T cell in the human body that can suppress the immune system. Later, they found that when defective, these so-called regulatory T cells can trigger some autoimmune diseases, especially multiple sclerosis (MS, multiple sclerosis). For many years, the molecular mechanisms behind this functional impairment have been unclear to researchers. Recently, a research report titled "An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction" was published in the journal Science Translational Medicin

Thu, 2024/08/29

AFDN Deficiency Promotes Hepatotropism in Metastatic Colorectal Cancer

The selective metastasis of cancer cells to specific organs is a complex process that is influenced not only by anatomical factors, but also by biological and organ-specific microenvironmental factors. The pre-metastatic niche refers to the soluble factors and extracellular vesicles (EVs) produced by cells at the site of the primary tumor, which can alter the microenvironment of distant organs to accommodate migrating cancer cells and promote their growth. In addition, disseminated tumor cells (DTCs) can enter a dormant state in circulation and new tissue environments, evad

Thu, 2024/08/29

Refresh The Size Limit Of Biological Proteins! The Synthesis Mechanism of the Largest Protein Discovered So Far

In a groundbreaking study, a research team from the Scripps Institution of Oceanography at the University of California, San Diego, revealed the secret of how a microalgae called Prymnesium parvum produces complex toxins. During this process, they discovered an unprecedentedly large protein in the field of biology, named PKZILLA-1. This discovery not only broke the record for protein size, but also opened the door to new drug development and material exploration. The relevant research results were published in the Science journal, under the title “Giant polyketide syn

Thu, 2024/08/29

Ketogenic Diet Forces Pancreatic Cancer to Change Its Metabolic Mode, Exposing Fatal Flaws!

We have previously reported various anti-cancer methods of a ketogenic diet. For example, improving the sensitivity of drug-resistant cancer cells to anticancer drugs; Reducing PD-L1 levels, and enhancing the anti-cancer effect of CTLA-4 inhibitors; And the ketone body β – hydroxybutyrate produced by the ketogenic diet directly inhibits the formation and development of colon cancer, and so on. Today, a research team led by Davide Ruggero from the University of California, San Francisco published a groundbreaking study in the top journal Nature. They fo

Thu, 2024/08/29

The Mechanism of Broad-Spectrum Anti Coronavirus Is Revealed By Capturing the Intermediate State of COVID-19 Spike Protein

Dr. Li Wenwei from Walther Mothes’ team at Yale University, along with doctoral students Michael Grunst and Dr. Qin Zhuan, published a research paper titled ” Structure and inhibition of SARS-CoV-2 spike refolding in membranes” in the journal Science. In this study, the research team used Cryo-electron tomography (Cryo-ET) to capture the structure of COVID-19 spike protein binding to the cell receptor ACE2 in the membrane, as well as the downstream conformational changes of its bottom protein S2, revealing the antiviral mechanism of the stem helix region bindin

Fri, 2024/07/19

The Dual Role of IRF1 in Cancer Therapy

Type I interferon (IFN-I) and IFN - γ can promote anti-tumor immunity by enhancing the body's T-cell response. Paradoxically, IFN - γ can promote T cell depletion by activating immune checkpoints. The downstream regulatory mechanisms of these different responses are currently unclear to researchers. Recently, a research report titled "Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity" was published in the journal Cell Reports. Scientists from the David Geffen School of Medicine at the University of California, and othe

Fri, 2024/07/19

A Novel Gene Therapy Is Expected To Treat Duchenne Muscular Dystrophy

The use of adeno-associated virus (AAV) vectors for gene replacement is a promising method for treating many diseases. However, the packaging capacity of AAV (approximately 4.7 kilobases) poses a challenge to this therapeutic approach, limiting its application in diseases associated with larger protein-coding sequences, such as Duchenne muscular dystrophy where mRNA is 14 kilobases. In a new study, researchers from the University of Washington have developed a novel gene therapy that utilizes the split intron-mediated protein trans-splicing mechanism to express larger dystrophin proteins, r

Fri, 2024/07/19

Not Everyone Is Suitable For Vegetarianism! Genetic Factors Play an Important Role in It

Vegetarian diet is widely praised for its benefits in reducing cholesterol, heart disease risk, and preventing type 2 diabetes, but researchers believe that this special diet may also have a cost. Recently, a research team from the University of Georgia revealed the important role of genetic factors in determining whether a vegetarian diet is suitable for individuals, providing a solid scientific basis for the development of personalized nutrition plans. The report was published in the international journal PLoS Genetics, titled "Gene-vegetarianism interactions in calcium, estimated glomeru