Creative Biomart Blog

Fri, 2024/07/19

ZAK Kinase Activates UV Mediated Programmed Cell Death

Ultraviolet (UV) radiation induces DNA damage and activates the DNA damage response (DDR) pathway, thereby blocking the cell cycle and allowing time for DNA repair. When DNA damage becomes severe and difficult to repair, it activates cell apoptosis. The study of UV radiation-induced DNA damage has long been well-known, but there is relatively little mention of how UV can also induce RNA damage. Research has found that UV can generate pyrimidine dimers and other light products through photochemical reactions, which can induce RNA damage within the transcriptome. UV damage can also lead to trans

Mon, 2024/07/01

IFITM5 Mutation Causes Abnormal Differentiation of Bone Marrow Cells, Leading To V-Type Osteogenesis Imperfect

In a new study, researchers from research institutions such as Baylor School of Medicine revealed the molecular events that lead to osteogenesis imperfecta type V. This discovery provides new possibilities for designing treatments for this incurable disease. The relevant research results were published online in the Journal of Clinical Investigation, under the title "The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect". V-type osteogenesis imperfecta is a brittle bone disease caused by a mutation in the IFITM5

Mon, 2024/07/01

MYCT1 Plays a Crucial Role in Self-Renewal of Human Hematopoietic Stem Cells

In a new study, researchers from the University of California, Los Angeles discovered a protein called MYCT1 that plays a crucial role in regulating self-renewal by helping human hematopoietic stem cells (HSCs) perceive and interpret signals from their environment. This discovery brings scientists one step closer to the method of amplifying hematopoietic stem cells in laboratory culture dishes, making it easier to obtain life-saving hematopoietic stem cell transplants and improving the safety of hematopoietic stem cell-based therapies such as gene therapy. The relevant research results were pu

Mon, 2024/07/01

Single Infusion of Long-Lived Multifunctional T Cells with IL4 Mutations Can Provide Lasting Relief for Asthma

In a new study, researchers from Tsinghua University in China found that genetically modified long-lived multifunctional T cells can inhibit the symptoms and signs of allergic asthma in mice for up to a year. Specifically, they genetically modified CAR-T cells to reduce the function of interleukins associated with type 2 high characteristic asthma. The relevant research results were published in the Nature Immunology journal, titled "A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice". Asthma is a disease characterized by infla

Mon, 2024/07/01

MSD PD-1 Inhibitor Approved By FDA for First-Line Treatment of Advanced Cancer

Keytruda is a PD-1 inhibitor developed by Merck, which can block the interaction between PD-1 and its ligands PD-L1 and PD-L2, release immune suppression mediated by the PD-1 signaling pathway, activate T lymphocytes that may affect tumor cells and healthy cells, and enhance the human immune system's ability to detect and eliminate cancer cells. Since obtaining FDA approval for the treatment of advanced melanoma for the first time in 2014, Keytruda has received FDA approval for the treatment of at least 16 types of cancer, as well as indications for unlimited cancer types. Our Featured Prod

Tue, 2024/06/11

Commonly Used Cholesterol Lowering Drugs, Statins, Can Prevent Cancer

Researchers from Harvard Medical School and Massachusetts General Hospital published a research paper in the journal Nature Communications titled: Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression. This study suggests that commonly used cholesterol-lowering drugs such as statins can prevent the progression of chronic inflammation to cancer by blocking the expression of interleukin-33 (IL-33). Our Related Proteins Cat. No. Product Name Species Source Tag IL33-122H Active Recombinant Human Interleukin 33, HIgG1 Fc-tagged, mutant Human CHO F

Tue, 2024/06/11

Liver ACOX1 Regulates Circulating Lipid Levels and Promotes Metabolic Health through Fat Remodeling

Obesity is a serious public health problem, which is related to a wide range of complications, including type 2 diabetes, cardiovascular disease, and liver steatosis. Dysfunction of lipid metabolism is a hallmark of obesity, related to the pathogenesis of these comorbidities. The imbalance between lipid synthesis and degradation leads to the accumulation of excess fat in adipose tissue and other organs. Brown adipose tissue (BAT) or related beige adipose tissue is an induced form of adipocytes produced by subcutaneous white adipose tissue (WAT) under certain external stimuli. Therapeutic ex

Tue, 2024/06/11

A Novel Therapy for Alzheimer's disease Targeting Neuronal Calcium Homeostasis

A new study published in the journal Science has brought us a new approach to the treatment of Alzheimer's disease (AD). Unlike many previous approaches to new drug development, this therapy does not target the key pathological proteins of Alzheimer's disease, beta-amyloid (Aβ) or tau protein, but rather targets the more fundamental neuronal calcium homeostasis. Calcium ion disorders play an important pathological role in various types of dementia, including AD. In the preclinical stage of the disease, calcium ion disorders have persisted and directly led to synaptic loss, which is a key pa