Creative Biomart Blog

Mon, 2024/01/22

CD276: A New Target for the Treatment of Brain Metastatic Cancer

Researchers from the University of Lausanne in Switzerland have published a research paper in the Cancer Cell journal titled “Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms”. Recent analysis of samples from patients with brain metastases (BrM) has revealed the importance of the brain tumor microenvironment (TME) in regulating the progression of primary and metastatic brain malignancies. The enormous complexity of TME in BrM is being revealed, with the immune cell landscape being the focus so far. However, there is currently a lack o

Sun, 2024/01/21

MRE11 Releases cGAS from Nucleosome Blockade to Prevent Cancer Development

Every time cancer cells divide, they cause damage to their own DNA molecules. For a long time, scientists including Gao á v Gupta Bo, associate professor of radiation oncology at the University of North Carolina School of Medicine in the United States, have been curious about how cancer can evade detection by the body's own defense system, despite the immune system constantly monitoring cells for DNA damage. In a new study, Gupta's laboratory revealed how the cGAS/STING pathway - a necessary pathway for activating inflammatory and immune responses within cells - can prevent cancer formation

Sun, 2024/01/21

Nuclear Membrane Proteins Promote Yellow Virus Replication

Yellow viruses, including dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV), are mostly transmitted through mosquito vectors and are currently one of the most widespread and highly infected infectious diseases, posing a huge threat to global public health. The infection of the yellow virus not only causes mild and self-limiting diseases (such as dengue fever and dengue hemorrhagic fever), but is also closely related to neurological diseases (such as neonatal microcephaly, encephalitis, Guillain-Barre syndrome, etc.). However, there are currently no targeted drugs in

Sun, 2024/01/21

In Situ Regeneration Research of Inner Hair Cells in a Mouse Injury Model Induced By Ectopic Expression of Tbx2 and Atoh1

The Development journal published a research paper online titled "In situ regeneration of inner hair cells in the damaged cochlea by temporally regulated coexpression of Atoh1 and Tbx2". The research was completed by Liu Zhiyong, a research group of the Center for Excellence and Innovation in Brain Science and Intelligent Technology (Institute of Neuroscience) of the Chinese Academy of Sciences, and the Shanghai Brain Science and Brain Research Center (Shanghai Brain Center). The research team constructed a mouse model of specific damage to cochlear inner hair cells, and based on this model, t

Sun, 2024/01/21

Research Progress on the Interaction Mechanism between Bunyavirus and Host

Recently, the team of Wang Hualin, Deng Fei, and Ning Yunjia from the Chinese Academy of Sciences Wuhan Virology Research Institute/National Viral Resource Bank published the research papers titled "Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins" and "Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity". The above research elucidates new interaction mechanisms between the virus and host cells of two highly pathogenic Bunyaviruses, CCHFV and SFTSV, expanding our underst

Tue, 2024/01/02

The Reasons for The Therapeutic Effect of CTLA-4 Inhibitors Being Sluggish

As the "predecessors" in immune checkpoint inhibitors, the development of anti-CTLA-4 monoclonal antibodies in recent years has not been ideal. From the perspective of approved indications, their single-drug treatment uses are few and can only be paired with PD-1/L1 inhibitors. If we look at the failure cases of clinical research, it will be even more heart-wrenching. So the question is, what is blocking the anti-CTLA-4 monoclonal antibody? The research findings just published by the Rockefeller University team in Cancer Immunology Research provide an explanation: the inhibitory IgG recepto

Tue, 2024/01/02

Protein IKAROS Regulates the Development of B Cells

The nucleus is a busy place. Cellular proteins twist and pull DNA, folding the genome into complex three-dimensional structures that support the function of its coding regions. This arrangement is crucial for cell development, but the specific steps for different types of cells vary greatly. Establishing correct communication between genes and distant control switches in the right cells at the right time is not an easy task. In fact, few proteins have the correct functional combination to organize the genome into the correct structure. In a new study, researchers from the La Jolla Institute

Tue, 2024/01/02

New Research Has Found Biomarkers for Predicting the Risk of Human Cell Aging and Death

As cells age, they experience aging, a state where they stop growing but continue to release inflammatory and tissue-degrading molecules. When a person is young, the immune system will respond by eliminating aging cells, commonly known as "zombie cells". However, zombie cells will continue to exist and lead to a series of age-related health problems and diseases. In a new study, researchers from the Mayo Clinic in the United States analyzed zombie cells and explained aging at the cellular level. They thus revealed the biological characteristics of aging cells. The relevant research results