Creative Biomart Blog

Tue, 2024/03/19

Activating GCN2 Can Metabolize Reprogrammed T Cells and Enhance Their Anti-Tumor Immunity

Researchers from the University of Toronto published a research paper titled “Ex vivo activation of the GCN2 pathway metabolically reprograms T cells, leading to enhanced adoptive cell therapy” in the Cell Reports Medicine journal. This study confirms that in vitro activation of the GCN2 pathway can metabolize reprogrammed T cells, thereby enhancing the therapeutic effect of adoptive cell therapy. Featured Products Cat. No. Product Name Source (Host) Species Tag EIF2AK4-3747HF Active Recombinant Full Length Human EIF2AK4 Protein, GST-tagged Insect (sf21) Human GST EIF2AK4-3346H Reco

Tue, 2024/03/19

RHBDL4 - A Novel Regulatory Mechanism for Controlling the Body's Immune System

Toll-like receptor 4 (TLR4) is a central regulatory factor of innate immunity in the body, mainly able to recognize the lipopolysaccharide cell wall components of bacteria and induce cytokine release. Recently, a research report titled "RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling" was published in Nature Communications. Scientists from institutions such as the University of Cologne found through their research that the membrane protease RHBDL4 may effectively prevent the occurrence of excessive immune responses in the body.

Tue, 2024/03/19

The Release of Special Inhibitory Pathways May Promote the Body's Immune Response against HIV Infection

During antiretroviral therapy, the persistent presence of HIV-1 may be due to its establishment of a long-lived virus library in quiescent immune cells. Recently, an article titled "TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo" was published in the international journal Nature Communications. In the research report, scientists from institutions such as Northwestern University in the United States used HIV-1 infection models to explore how inhibiting immune cell signaling pathways combined with antiretroviral ther

Tue, 2024/03/19

Regulatory Mechanism of RAS Palmitoyltransferase

RAS participates in multiple signaling pathways, and post-translational modifications regulate the subcellular localization of RAS to regulate downstream signal transduction. Among them, palmitoylation is a necessary modification of HRAS and NRAS signal transduction. The acyltransferase DHHC9 binds to the helper protein GCP16 to catalyze palmitoylation of HRAS and NRAS, but the interaction between GCP16 and DHHC9, as well as the molecular mechanism by which GCP16 regulates the palmitoylation activity of DHHC9, remain unclear. The Hu Qi and Wu Jianping team from the School of Life Sciences a

Tue, 2024/03/19

Revealing Prognostic Markers for Small Cell Lung Cancer

In a new study, a research team led by Professor Zhang Peng of the Shanghai Lung Hospital affiliated with Tongji University, China, Professor Zhou Hu of the Chinese Academy of Sciences Shanghai Institute of Materia Medica, Professor Gao Daming and Ji Hongbin of the Molecular Cell Science Innovation Center of the Chinese Academy of Sciences Shanghai Institute of Biochemistry and Cell Biology has reported for the first time a large-scale study on the proteomic and phosphorylated proteomic characteristics of clinical cohorts of small cell lung cancer (SCLC), providing a comprehensive overview of

Tue, 2024/03/19

The Molecular Mechanism of Fusion Protein Intercepting Gene Regulators and Inducing Childhood Cancer

The occurrence of many childhood cancers often begins with molecular hijacking. Recently, a research report titled "Heterotypic interactions can drive selective co-condensation of prion-like low-complexity domains of FET proteins and mammalian SWI/SNF complex" was published in the journal Nature Communications. Scientists from institutions such as the University of Buffalo revealed through their research how fusion proteins intercept gene regulators to stimulate the development of cancer in children. In the article, researchers found that a group of abnormal proteins called fusion proteins

Tue, 2024/03/19

Research Progress on Structural Characteristics and Enzyme Activity Regulation Mechanisms of Viral Topoisomerases

Recently, Deng Zengqin's team from the Chinese Academy of Sciences Wuhan Virus Research Institute/Antiviral Research Center completed the latest research achievement entitled “Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase”, which was published online on mBio. DNA topoisomerases are widely present in archaea, prokaryotes, eukaryotes, and some nuclear-cytoplasmic large DNA viruses, playing important roles in gene replication, transcription, recombination, and chromosome separation processes. DNA topoisomerase is a target for various anti-tumor and

Tue, 2024/03/19

The Influence of Age and Number of Mutations on the Size of Clonal Hematopoiesis

Hainan Medical College's Ren Ruibao, Cai Wangwei, and Shanghai Jiao Tong University's Chen Zhu jointly published a research paper on PNAS titled "The impact of age and number of mutations on the size of clonal hematopoiesis", which reported an in-depth analysis of Clonal Hematopoiesis (CH) in the elderly population with longevity (age ≥ 90 years old) and general health (age 60-89 years old). This study utilized targeted deep sequencing and found that the occurrence and development of CH are closely related to the expression of age and aging biomarkers. The incidence of CH in the elderly gro