Creative Biomart Blog

Thu, 2024/08/29

The Mechanism of Broad-Spectrum Anti Coronavirus Is Revealed By Capturing the Intermediate State of COVID-19 Spike Protein

Dr. Li Wenwei from Walther Mothes’ team at Yale University, along with doctoral students Michael Grunst and Dr. Qin Zhuan, published a research paper titled ” Structure and inhibition of SARS-CoV-2 spike refolding in membranes” in the journal Science. In this study, the research team used Cryo-electron tomography (Cryo-ET) to capture the structure of COVID-19 spike protein binding to the cell receptor ACE2 in the membrane, as well as the downstream conformational changes of its bottom protein S2, revealing the antiviral mechanism of the stem helix region bindin

Fri, 2024/07/19

The Dual Role of IRF1 in Cancer Therapy

Type I interferon (IFN-I) and IFN - γ can promote anti-tumor immunity by enhancing the body's T-cell response. Paradoxically, IFN - γ can promote T cell depletion by activating immune checkpoints. The downstream regulatory mechanisms of these different responses are currently unclear to researchers. Recently, a research report titled "Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity" was published in the journal Cell Reports. Scientists from the David Geffen School of Medicine at the University of California, and othe

Fri, 2024/07/19

A Novel Gene Therapy Is Expected To Treat Duchenne Muscular Dystrophy

The use of adeno-associated virus (AAV) vectors for gene replacement is a promising method for treating many diseases. However, the packaging capacity of AAV (approximately 4.7 kilobases) poses a challenge to this therapeutic approach, limiting its application in diseases associated with larger protein-coding sequences, such as Duchenne muscular dystrophy where mRNA is 14 kilobases. In a new study, researchers from the University of Washington have developed a novel gene therapy that utilizes the split intron-mediated protein trans-splicing mechanism to express larger dystrophin proteins, r

Fri, 2024/07/19

Not Everyone Is Suitable For Vegetarianism! Genetic Factors Play an Important Role in It

Vegetarian diet is widely praised for its benefits in reducing cholesterol, heart disease risk, and preventing type 2 diabetes, but researchers believe that this special diet may also have a cost. Recently, a research team from the University of Georgia revealed the important role of genetic factors in determining whether a vegetarian diet is suitable for individuals, providing a solid scientific basis for the development of personalized nutrition plans. The report was published in the international journal PLoS Genetics, titled "Gene-vegetarianism interactions in calcium, estimated glomeru

Fri, 2024/07/19

ZAK Kinase Activates UV Mediated Programmed Cell Death

Ultraviolet (UV) radiation induces DNA damage and activates the DNA damage response (DDR) pathway, thereby blocking the cell cycle and allowing time for DNA repair. When DNA damage becomes severe and difficult to repair, it activates cell apoptosis. The study of UV radiation-induced DNA damage has long been well-known, but there is relatively little mention of how UV can also induce RNA damage. Research has found that UV can generate pyrimidine dimers and other light products through photochemical reactions, which can induce RNA damage within the transcriptome. UV damage can also lead to trans

Mon, 2024/07/01

IFITM5 Mutation Causes Abnormal Differentiation of Bone Marrow Cells, Leading To V-Type Osteogenesis Imperfect

In a new study, researchers from research institutions such as Baylor School of Medicine revealed the molecular events that lead to osteogenesis imperfecta type V. This discovery provides new possibilities for designing treatments for this incurable disease. The relevant research results were published online in the Journal of Clinical Investigation, under the title "The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect". V-type osteogenesis imperfecta is a brittle bone disease caused by a mutation in the IFITM5

Mon, 2024/07/01

MYCT1 Plays a Crucial Role in Self-Renewal of Human Hematopoietic Stem Cells

In a new study, researchers from the University of California, Los Angeles discovered a protein called MYCT1 that plays a crucial role in regulating self-renewal by helping human hematopoietic stem cells (HSCs) perceive and interpret signals from their environment. This discovery brings scientists one step closer to the method of amplifying hematopoietic stem cells in laboratory culture dishes, making it easier to obtain life-saving hematopoietic stem cell transplants and improving the safety of hematopoietic stem cell-based therapies such as gene therapy. The relevant research results were pu

Mon, 2024/07/01

Single Infusion of Long-Lived Multifunctional T Cells with IL4 Mutations Can Provide Lasting Relief for Asthma

In a new study, researchers from Tsinghua University in China found that genetically modified long-lived multifunctional T cells can inhibit the symptoms and signs of allergic asthma in mice for up to a year. Specifically, they genetically modified CAR-T cells to reduce the function of interleukins associated with type 2 high characteristic asthma. The relevant research results were published in the Nature Immunology journal, titled "A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice". Asthma is a disease characterized by infla