Creative Biomart Blog

Fri, 2023/05/12

Molecular Mechanism of Melanoma Induced by CDK13 Mutant Protein

The RNA surveillance pathway can detect and interpret defective transcripts to ensure the fidelity of RNA. Recently, in a research report entitled "Oncogenic CDK13 mutations infinite nuclear RNA surveillance" published on the international journal Science, scientists from Howard Hughes Medical Research Institute and other institutions found a new mechanism that affects the occurrence of melanoma through research, which has a very broad and important significance for the treatment of multiple cancer patients. In the article, researchers focused on studying a protein called CDK13, which was p

Tue, 2023/04/25

Novel CAR-T Cell Therapy with Potential for Treating Human Solid Tumors

Because of the expansion and persistence of CAR-T cells, patients receiving CAR-T cells rich in memory T cells tend to have better disease control. Human memory T cells, including stem cell-like CD8+memory T cell progenitors, will become functional stem cell-like T cells (TSTEM) or dysfunctional T group cells (TPEX). Recently, a research report entitled “T STEM like CAR-T cells exhibit improved persistence and transformer control compared with conventional CAR-T cells in preclinical models” was published in the international journal Science Translational Medicine. Scientists from Melbourne Uni

Tue, 2023/04/25

PROTAC R&D to Achieve the Latest Progress

Recently, the Li Zigang/Yin Feng research group at the Shenzhen Graduate School of Peking University published a research paper titled “Targeted biomolecule regulation platform: a Split and Mix PROTAC approach” in the Journal of the American Chemical Society, reporting peptide self-assembly formed Split and Mix PROTAC (SM PROTAC), which achieved significant degradation effects on multiple targets, such as ERα, EGFR, MEK1/2, BRD2/4, CDK4/6, AR, BCR-ABL, etc. Targeted protein degradation technology (PROTAC), as an emerging protein degradation technology, has potential advantages over small mo

Tue, 2023/04/25

Discovering an Autoimmune Inflammatory Disease Induced by LYN Gene Mutation

Scientists from institutions such as the National Institute of Allergy and Infectious Diseases in the United States have identified an autoimmune disease induced by mutations in the LYN gene, which is an important regulator of the body's immune response in both healthy and diseased states. Neutrophilic inflammation is a hallmark of the occurrence of many monogenic autoimmune diseases. Currently, researchers are not very clear about the pathological mechanisms that regulate the spillover of destructive immune cells into surrounding tissues. Recently, in a research report published in the inte

Tue, 2023/04/25

Special Protein FAM193A with Novel Anti-Tumor Activity

Scientists from institutions such as the Anschutz School of Medicine at the University of Colorado have discovered and characterized a specific protein that is primarily involved in the specific mechanisms that inhibit the progression of different types of tumors. Understanding how cancer occurs is crucial for designing effective personalized cancer therapies. For many years, researchers have known that cancer begins with mutations in certain types of genes, one of which is called “tumor suppressors”, Tumor suppressor genes block uncontrolled cell proliferation in malignant cells and initia

Thu, 2023/03/30

M6A Targeted Modification Can Improve Immune checkpoint Therapy

The immune system acts as a guardian of the host by initiating an immune response to harmful pathogens and tumor cells. However, overreaction is the cause of chronic or excessive inflammation and autoimmune diseases. Immune checkpoints play a key role in regulating the size of immune responses, thereby maintaining immune homeostasis and self-tolerance. However, tumor cells can also use immune checkpoints to evade immune surveillance, suppress anti-tumor immune responses, and ultimately lead to tumor genesis and tumor progression. Recently, researchers from Qilu Medical College published an

Thu, 2023/03/30

The Role of the Third Intracellular Ring of GPCR in GPCR Signal Conduction Mechanism

In a new study, American researchers have discovered the role of the third intracellular loop of GPCR in the GPCR signal transduction mechanism, indicating the possibility of adopting more targeted drug discovery methods and developing new drugs. More than one-third of the drugs approved by the United States Food and Drug Administration (FDA) function by targeting G protein-coupled receptors (GPCRs). The human body has over 800 types of GPCRs, which provide cells with information about the external environment to calibrate the body's response. Drugs that block or activate GPCR are used to t

Thu, 2023/03/30

The Base Editor Is Expected to Be Used for the Treatment of CD3Δ Severe Combined Immunodeficiency

In a new study, researchers from research institutions such as the University of California, Los Angeles, discovered that advanced genome editing technology may be able to be used for a rare and fatal genetic disease, D3 delta severe combined immunodeficiency, CD3δ SCID, for a one-time treatment. The relevant research results were published online in Cell, with the title “Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing”. CD3δ SCID is caused by a mutation in the CD3D gene, which blocks the production of CD3δ proteins that are required