Creative Biomart Blog

Fri, 2023/07/21

Intranasal injection of human mitochondrial protein alleviates the progression of Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disease, which has become a serious problem worldwide. The typical clinical features of Parkinson's disease include motor manifestations such as bradykinesia, static tremors, and postural instability. Although several physiological processes are related to the pathogenesis of Parkinson's disease, some studies have reported the central role of mitochondrial dysfunction in the pathogenesis of Parkinson's disease. Recently, researchers from the Department of Health Sciences at the Graduate School of Donga University in South Korea publishe

Sat, 2023/07/01

Structure and Function of the RAD51B-RAD51C-RAD51D-XRCC2 Protein Complex

Homologous recombination is a basic process of life, which is necessary to protect and restart broken replication forks, repair chromosome breaks and exchange genetic material during meiosis. Recently, in a research report titled “Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumor suppressor complex” published in the journal Nature, scientists from institutions such as the Francis Crick Institute summarized the structure and function of a special protein complex, which is crucial for repairing damaged DNA and protecting the body against cancer. Every time when cells replicate, e

Sat, 2023/07/01

B4GALT1 Promotes Immune Escape in Lung Adenocarcinoma

With the popularization of lung cancer screening and the clinical application of computed tomography (CT), the number of detected pulmonary nodules has significantly increased, many of which are adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC). After surgical resection, the 5-year survival rate of AIS and MIA is close to 100%, and the recurrence rate is 0%, while IAC does not have such good survival benefits. Several professional societies have revised the classification of lung adenocarcinoma (LUAD) and its precursors, including the e

Sat, 2023/07/01

Mutated TG2 Enzyme Promotes the Progression and Diffusion Mechanism of Prostate Cancer

In a new study, researchers from Nottingham Trent University in the UK identified how a specific enzyme plays a key role in making prostate cancer more invasive and difficult to treat. They found that this enzyme, called transglutaminase 2 (TG2), which is abundant in many cells of the body, is responsible for driving the process leading to the progression and spread of prostate cancer. The relevant research results have recently been published in the journal Cell Death & Disease, with the title “Canonical and truncated transglutaminase-2 regular mucin-1 expression and androgen dependence i

Fri, 2023/06/30

By Activating Oct4, Premature Aging Mouse Cells Can Recover Their Vitality

Aging seems to be an irresistible natural law, and at the same time, how to “fight aging and achieve immortality” has become an eternal research topic. Nowadays, thanks to the rapid development of biotechnology, research on anti-aging has become increasingly popular. In 2006, the team of Shinya Yamanaka of Kyoto University in Japan first reported related research on induced pluripotent stem cells (iPSC). They found that by introducing four transcription factors, Oct4, Sox2, c-Myc, and Klf4, the terminally differentiated Somatic cell can be “reprogrammed” into pluripotent stem cells, which a

Mon, 2023/05/15

Three Dimensional Structure of the Smallest Programmable Nuclease Tnpb

In a new study, professor Virginijus Šikšnys from the Life Sciences Center (VU-LSC) of Vilnius University in Lithuania and his research team cooperated with Professor Guillermo Montoya of the Novo Nordisk Foundation Protein Research Center (CPR) of the University of Copenhagen in Denmark and his research team to determine the structure of TnpB using Cryo-EM. The relevant research results were published in Nature on April 13, 2023, with the title “TnpB structure requires minimal functional core of Cas12 nuclease family”. CRISPR Cas nuclease, such as Cas9 or Cas12, also known as gene scissors

Mon, 2023/05/15

Scientists Have Screened New Serotonin Transporter Inhibitors From Over 20 Billion Molecules

Highlights •Large-library docking finds conformationally and target-selective SERT inhibitors •Cryo-EM supports the computationally predicted structure •The inhibitors are anti-depressant-like and alleviate opioid withdrawal in mice •Targeting of transporters for structure-based ligand discovery 5-hydroxytryptamine transporter (SERT) is a common target for antidepressants as it can "transport" serotonin from synapses. Transporting protein transporters is a process of "swallowing and vomiting", completed by alternating protein conformations opening outward and inward. Research has shown t

Fri, 2023/05/12

Insufficient Sleep Can Lead to Dementia, Affecting the Clearance of Toxic Proteins in the Brain and Increasing the Risk of Dementia

This study reveals how sleep deprivation affects microglia, and finds that TREM2 mediates sleep deprivation-induced microglia overactivation, and β-Amyloid protein (Aβ） deposition increases. Long-term chronic sleep deprivation regulates inflammation and the metabolic reaction of microglia and Aβ in the brain. With the accelerating pace of society and increasing work pressure, it is sometimes particularly luxurious for modern people to have a good sleep. However, a large number of studies have shown that the quality of sleep is closely related to people's physical and mental health. Takin