Creative Biomart Blog

Fri, 2023/09/22

In Situ PEG Modification of CAR-T Cells Can Alleviate Cytokine Release Syndrome and Neurotoxicity

In recent years, cancer researchers have cheered the arrival of chimeric antigen receptor (CAR) T-cell therapy, which has achieved encouraging results and changed the treatment methods of various cancers. CAR-T cell therapy targets cancer cells through genetically modified patients' T cells, thereby achieving a significant cure rate for previously incurable cancers. Currently, six CAR-T cell therapies have been approved by the US Food and Drug Administration (FDA), and several are under development. However, these cell therapies also have serious potential fatal side effects, namely cytokin

Thu, 2023/08/17

Scientists have found 32 proteins related to dementia in the blood of middle-aged people based on 25 years of data!

Genome-wide association studies on Alzheimer's disease (AD) have shown that its biological process is very complex and not limited to the accumulation of β Amyloid protein (Aβ）and tau protein. Systemic factors and biological processes outside the central nervous system may also affect the risk of dementia and AD. Proteins, as systemic circulating factors, may be driving factors for complex central nervous system diseases, and researchers have been searching for biomarkers in plasma that can represent pathological progression. However, currently, large-scale proteomic analysis of dementia is

Thu, 2023/08/17

Host Limiting Factor ProtΑ can Inhibit HIV Infection in the Body

In a new study, researchers from research institutions such as the Walter Reed Army Research Institute in the United States confirmed previous research on host limiting factors for HIV-1. They detailed how omics reveal correlations when searching for treatment strategies. The relevant research results were published in the issue of the Science Translational Medicine journal, with the title “Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo.” These authors used single-cell transcriptomics to identify proteins active in the cells of 14 HIV-1 infected individual

Thu, 2023/08/17

Drugs Targeting the Protein Cypa Have the Potential to Treat a Range of Poxviruses, Including Monkeypox and Smallpox Viruses

In a new study, researchers from the University of Oxford, the University of Cambridge, and the Pierbright Institute in the UK have discovered a new treatment method that may be more durable than current methods when studying how the pox virus evades the natural defense function of human cells. Prior to this, they discovered how the pox virus hijacks a cellular protein to evade the host cell's defense, thereby effectively replicating and spreading. The relevant research results were published online in the journal Nature, with the title “TRIM5α restricts poxviruses and is antagonized by CypA a

Tue, 2023/08/15

A Novel Mechanism of ID1 Regulation in the Initiation and Progression of Acute Myeloid Leukemia in the Bone Marrow Microenvironment

Wang Lan's research group of the Chinese Academy of Sciences Shanghai Institute of Nutrition and Health published the research achievement entitled “The cell non-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment” online on Blood. This study reveals the key role of transcription regulatory factor ID1 in the bone marrow microenvironment in the initiation and progression of acute myeloid leukemia (AML), providing new ideas and strategies for the treatment of AML. AML is a malignant disease originating from hematopoietic stem/progenitor cells. Its charact

Wed, 2023/07/26

TLR9 Agonists Can Act As In Situ Anti-Tumor Vaccines

Osteosarcoma (OS) is a highly malignant stromal tumor composed of mesenchymal cells that produce osteoid and immature bone. The peak of incidence is in the second decade after birth. Although relatively rare, the social impact of this type of tumor is particularly relevant. In contrast to cancer, the role of Molecular genetics of Osteosarcoma progression and its special Tumor microenvironment (TME) - bone - remains largely unknown. Although TME has been widely studied in other solid tumors to describe its role in tumor progression and some in a distant spread, research on tumor interstitial

Tue, 2023/07/25

TRAF2 Is a Potential New Target for the Treatment of Advanced Renal Cell Carcinoma

Renal cell carcinoma (RCC) is one of the top ten most common malignant tumors in both males and females worldwide, accounting for 4.2% of all new cancer cases. Clear cell carcinoma of the kidney (Ccrcc) is the most common histological subtype, originating from the proximal renal epithelial tubules and being the cause of most cancer-related deaths. It is difficult to detect early, resulting in approximately 30% of ccRCC patients already experiencing distant metastasis at diagnosis. In recent years, the clinical application of targeted therapy and immunotherapy has improved the overall surviv

Fri, 2023/07/21

PPARΑ Pretreatment of Agonist WY14643 Reduced Cardiomyopathy Caused By Mitochondrial Dysfunction in the Hearts of Lipopolysaccharide Treated Mice

Sepsis is defined as Systemic inflammatory response syndrome (SIRS), which is the most common cause of death in ICU. The main reason for the increased mortality rate of sepsis is septic shock. Septicemia continuously damages the cardiovascular system, and cardiac dysfunction is the main cause of septic shock. Therefore, there is an urgent need for new mechanisms and effective treatment methods to treat cardiac dysfunction caused by sepsis. Recently, researchers from Capital Medical University published a report on Acta Pharmalogica Sinica magazine entitled “Cardiomyocyte peroxisome prolifer