Creative Biomart Blog

Tue, 2024/02/20

The Mechanism by Which Leukemia Stem Cells Promote Their Own Growth after Chemotherapy

The mystery of why myeloid leukemia begins to grow again after chemotherapy kills most malignant cells and how to prevent growth through reused drugs may be solved through new research. The bone marrow of patients with acute myeloid leukemia (AML) contains a rare group of leukemia stem cells (LSCs) that do not grow and therefore are not killed by chemotherapy. However, after treatment, these cells began to grow and produce AML cells, but it is currently unclear what initiated this process. In a new study, researchers from the University of Birmingham, Newcastle University, and Princess M

Tue, 2024/02/20

How HIV Capsid Enters the Nuclear Pore Barrier Pathway

In a new study, Dr. David Jacques, a medical researcher at the University of New South Wales in Australia, and his team discovered how the human immunodeficiency virus (HIV) breaks through the nucleus to establish infection, a discovery that goes beyond the scope of HIV biology. The relevant research results were published online in the journal Nature, with the title "The HIV capsid mimics karyopherin engagement of FG-nucleoporins". To infect cells, HIV must enter the target cell and reach the nucleus located at the center of the cell, where it produces enough copies of the genetic code to

Sun, 2024/02/18

The Special Protective Effects of Breast Milk

Breastfeeding can provide significant health benefits for newborns and infants by providing nutrition, immune protection, and shaping the gut microbiota. Although scientists have long believed that breast milk contains complement components, the physiological correlation of complement components in breast milk is not clear to them. Recently, a research report titled "Complement in breast milk modifies offspring gut microbiota to promote infant health " was published in the journal Cell. Scientists from institutions such as Johns Hopkins University found through their research that immune compo

Sun, 2024/02/18

Reveal A New Immune Pathway for The Treatment of Bone Metastasis in Breast Cancer

Immunotherapy is a very promising method for the treatment of metastatic breast cancer, which can provide new possibilities for treatment. Although checkpoint inhibitors show some hope in the treatment of metastatic breast cancer, their therapeutic effect on patients with bone metastases is disappointing. The lack of such efficacy seems to have a certain specificity for the bone environment, which will show the characteristics of avoiding inhibition. Recently, a research report titled "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis" was publish

Sun, 2024/02/18

PLA2G7-A New Breakthrough in Reversing the Immunosuppressive Microenvironment of Liver Cancer

Recently, a team led by Dong Ling from Zhongshan Hospital affiliated with Fudan University and Zhang Si from the School of Basic Medicine at Fudan University jointly published a new study in the Journal for ImmunoTherapy of Cancer, revealing the presence of a class of highly expressed platelet-activating factor acetylhydrolase (PLA2G7) and highly immunosuppressive TAMs in the microenvironment of hepatocellular carcinoma (HCC). Inhibiting PLA2G7 can improve the immune microenvironment and reinforce HCC immunotherapy. Intervention of TAMs to enhance HCC immunotherapy has been a research focus

Sun, 2024/02/18

Acinar-Ductal Cell Rearrangement Drives Branching Morphogenesis of the Murine Pancreas in an IGF/PI3K Dependent Manner

Many epithelial organs undergo branching morphogenesis during development, resulting in the construction of complex dendritic networks and the acquisition of specialized tissue structures. Understanding the establishment and maintenance of organizational structure is a core issue in developmental biology, which directly impacts organ physiology and diseases. In adult life, the loss of organizational structure may occur in the early stages and various human cancers. However how these processes are coordinated and how to preserve tissue structure in the event of severe cell rearrangement during

Mon, 2024/01/22

The New Role of STING in the Human Innate Immune System

When pathogens invade the body, the innate immune system will play a role in resisting the invading pathogens. The innate immune system is the first line of defense. It can accurately detect viruses or bacteria, and then activate proteins to fight against pathogens. In order to better understand the working principle of the innate immune system in the body, researchers from research institutions such as the National Cancer Center Research Institute, Tohoku University, and Gifu University in Japan conducted a new study on STING, a protein that plays an important role in innate immunity. Their r

Mon, 2024/01/22

Molecular Mechanisms Underlying the Development of Colitis in Cancer Immunotherapy Induced Patients

Immune checkpoint inhibitors can stimulate the body's anti-tumor immune system, but they can also have toxic effects called immune-related adverse events (irAEs). Colitis is a common and serious immune-related adverse event that can cause treatment interruption. As researchers did not observe a strong colitis response in laboratory mice treated with checkpoint inhibitors, Therefore, the understanding of the underlying mechanisms of intestinal immune-related adverse events is often hindered. Recently, an article titled "Microbiota-dependent activation of CD4 + T cells induces CTLA-4 blockade–as