Creative Biomart Blog

Tue, 2024/03/19

Regulatory Mechanism of RAS Palmitoyltransferase

RAS participates in multiple signaling pathways, and post-translational modifications regulate the subcellular localization of RAS to regulate downstream signal transduction. Among them, palmitoylation is a necessary modification of HRAS and NRAS signal transduction. The acyltransferase DHHC9 binds to the helper protein GCP16 to catalyze palmitoylation of HRAS and NRAS, but the interaction between GCP16 and DHHC9, as well as the molecular mechanism by which GCP16 regulates the palmitoylation activity of DHHC9, remain unclear. The Hu Qi and Wu Jianping team from the School of Life Sciences a

Tue, 2024/03/19

Revealing Prognostic Markers for Small Cell Lung Cancer

In a new study, a research team led by Professor Zhang Peng of the Shanghai Lung Hospital affiliated with Tongji University, China, Professor Zhou Hu of the Chinese Academy of Sciences Shanghai Institute of Materia Medica, Professor Gao Daming and Ji Hongbin of the Molecular Cell Science Innovation Center of the Chinese Academy of Sciences Shanghai Institute of Biochemistry and Cell Biology has reported for the first time a large-scale study on the proteomic and phosphorylated proteomic characteristics of clinical cohorts of small cell lung cancer (SCLC), providing a comprehensive overview of

Tue, 2024/03/19

The Molecular Mechanism of Fusion Protein Intercepting Gene Regulators and Inducing Childhood Cancer

The occurrence of many childhood cancers often begins with molecular hijacking. Recently, a research report titled "Heterotypic interactions can drive selective co-condensation of prion-like low-complexity domains of FET proteins and mammalian SWI/SNF complex" was published in the journal Nature Communications. Scientists from institutions such as the University of Buffalo revealed through their research how fusion proteins intercept gene regulators to stimulate the development of cancer in children. In the article, researchers found that a group of abnormal proteins called fusion proteins

Tue, 2024/03/19

Research Progress on Structural Characteristics and Enzyme Activity Regulation Mechanisms of Viral Topoisomerases

Recently, Deng Zengqin's team from the Chinese Academy of Sciences Wuhan Virus Research Institute/Antiviral Research Center completed the latest research achievement entitled “Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase”, which was published online on mBio. DNA topoisomerases are widely present in archaea, prokaryotes, eukaryotes, and some nuclear-cytoplasmic large DNA viruses, playing important roles in gene replication, transcription, recombination, and chromosome separation processes. DNA topoisomerase is a target for various anti-tumor and

Tue, 2024/03/19

The Influence of Age and Number of Mutations on the Size of Clonal Hematopoiesis

Hainan Medical College's Ren Ruibao, Cai Wangwei, and Shanghai Jiao Tong University's Chen Zhu jointly published a research paper on PNAS titled "The impact of age and number of mutations on the size of clonal hematopoiesis", which reported an in-depth analysis of Clonal Hematopoiesis (CH) in the elderly population with longevity (age ≥ 90 years old) and general health (age 60-89 years old). This study utilized targeted deep sequencing and found that the occurrence and development of CH are closely related to the expression of age and aging biomarkers. The incidence of CH in the elderly gro

Tue, 2024/03/19

Genetic Anxiety Switch in the Body

Recently, a research report titled "An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behavior in mice and humans" was published in the journal Molecular Psychology. Scientists from institutions such as the University of Aberdeen found through their research that special DNA regions in the human genome may play an important role in controlling anxiety disorders in the body, this key gene may affect the anxiety level of the mouse body. According to data from the Mental Health Foundation, after the COVID-19 pandemic, the proportion of

Tue, 2024/02/20

TRIB3-TRIM8 Complex Regulates HNF4Α Stability to Promote the Progression of Non-Alcoholic Fatty Liver Disease

Hepatocellular endoplasmic reticulum stress plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Hepatonuclear factor 4 α (HNF4α) reduced expression is an important event in the pathogenesis of non-alcoholic fatty liver and other liver diseases. Does endoplasmic reticulum stress regulate the expression of HNF4α is not clear yet. The purpose of this study is to elucidate the mechanism of HNF4 α protein degradation and exploration of treatment strategies protecting HNF4α stability during the progression of non-alcoholic fatty liver disease. Recently, resea

Tue, 2024/02/20

Potential Therapeutic Targets for Human Inflammatory Bowel Disease and Colitis Induced Colorectal Cancer

Intestinal inflammation can trigger a vicious cycle that disrupts the sensitive relationships between food, digestive acids, microorganisms, and the immune system, further promoting inflammation and sometimes even leading to tumor growth; Recently, a research report published in the journal JCI Insight titled "Farnesoid X receptor mediates macrophage-intrinsic responses to suppress colitis-induced colon cancer progression," scientists from institutions such as the University of Wisconsin Madison identified a promising new target for developing new therapies through their research, It may poten