Uncategorized Thursday, 2024/10/17
Yes related proteins (YAP) and their homologs, transcription co-activators carrying PDZ binding motifs (TAZ), are the main downstream effectors of the Hippo signaling pathway. Recently, a research report titled "A non-canonical repressor function of JUN restrains YAP activity and liver cancer growth" was published in the journal EMBO Journal. Scientists from institutions such as the Fritz Lipmann Institute in Germany discovered an additional control mechanism that can prevent liver cancer growth through their research.
In the article, researchers found that JUN protein plays a decisive role in inhibiting YAP and TAZ, both of which strongly promote tumor formation in the body when dysfunctional. This is a new discovery made by researchers accidentally while analyzing data from more than 8000 patients. At the same time, they also realized the abnormalities that occur in the bodies of liver cancer patients. This research finding provides a new perspective for cancer research and is expected to help develop new innovative therapeutic strategies, as targeting the function of JUN protein may potentially control or even prevent the progression of liver cancer.
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| Cat.No. # | Product Name | Source (Host) | Species | Tag | Protein Length | Price |
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| JUN-1027H |
Active Recombinant Human Jun Oncogene
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Insect Cell | Human | Non | 1-331 aa | |
| JUN-105H |
Active Recombinant Human JUN, His-tagged
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Insect Cell | Human | His |
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| JUN-8483H | Recombinant Human JUN, His-tagged | E.coli | Human | His | 1-331 | |
| TAZ-1227H | Recombinant Human TAZ protein, His & T7-tagged | E.coli | Human | His&T7 | Gly154~Arg292 |
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| TAZ-30938TH | Recombinant Human TAZ | Wheat Germ | Human | Non | 262 amino acids |
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| TAZ-522HF | Recombinant Full Length Human TAZ Protein | In Vitro Cell Free System | Human | Full L. 262 amino acids |
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| YAP1-18H | Recombinant Human YAP1 protein, GST-tagged | Wheat Germ | Human | GST | 1-504 a.a. |
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| YAP1-19H | Recombinant Human YAP1 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| YAP1-3761H | Recombinant Human YAP1, GST-tagged | E.coli | Human | GST | 155-504aa | |
| YAP1-3775H | Recombinant Human YAP1 protein, His-B2M-tagged | E.coli | Human | His&B2M | 1-504aa |
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Under normal circumstances, the activity of YAP and TAZ is controlled by the so-called Hippo signaling pathway. However, in this study, researchers demonstrated that JUN can directly inhibit the activity of these cancer growth-promoting proteins. They described it as an additional control mechanism that can go beyond the Hippo signaling pathway. In addition, especially in liver cancer, researchers found that erroneous regulation of JUN can also lead to uncontrolled activation of YAP and TAZ, thereby promoting tumor growth.
Therefore, JUN can perform two basic functions, namely its involvement in inflammatory and regenerative processes in body cells. This dual function may significantly affect the occurrence of cancer and other diseases, as well as how future researchers can treat them. So what factors can determine whether JUN regulates the inflammatory or regenerative processes of the body, there is still no answer. In summary, the research findings of this article elucidate additional control mechanisms for the interaction between YAP/TAZ and JUN.
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Reference
Yuliya Kurlishchuk,Anita Cindric Vranesic,Marco Jessen, et al. A non-canonical repressor function of JUN restrains YAP activity and liver cancer growth, The EMBO Journal (2024). DOI:10.1038/s44318-024-00188-0