Creative Biomart Blog

Tue, 2018/12/04

New Drug Targets That Are Expected to Treat Malignant Cancer Discovered

Recently, scientists from the Dana-Farber Cancer Institute have discovered new drug targets for two malignant cancers. It is expected to develop new therapies for the treatment of synovial sarcoma and malignant rods-shaped tumors. Related research result was published in the Nature Cell Biology. The researchers say that these two cancers depend on a new molecular called ncBAF, which plays a key role in regulating gene activity, consisting of multiple specific protein subunits. Biologically or chemically inactivating components of ncBAF may specifically impair proliferation of synovial sarco

Mon, 2018/11/19

Herpes Virus Is One of the Causes of Alzheimer's Disease!

Alzheimer's disease is one of the most common forms of dementia. More than 30 million people worldwide suffer from Alzheimer's disease. Unfortunately, there is currently no cure for the disease, only drugs that relieve the symptoms of the patient; in a recently published dissertation, the author (Professor Ruth Itzhaki of the University of Manchester) proposed a new method for the treatment of Alzheimer's disease. The researchers pointed out that some studies have shown that herpes virus may be one of the reasons inducing Alzheimer's disease. Therefore, effective and safe antiviral drugs may b

Wed, 2018/11/14

Progress in HIV Research in October 2018 (II)

(...Continued) JCI: Infectious HIV is not present in liver macrophages of HIV-infected patients receiving treatment doi:10.1172/JCI121678 In a new study, researchers from Johns Hopkins University and Los Alamos National Laboratory determined whether liver macrophages are infectious HIV-1 virus pools after ART treatment. The real source of the liver tissue samples from nine HIV-1 infected individuals (7 of them were transplanted at Johns Hopkins Hospital). Eight of these nine patients received ART treatment from 8 months to 140 months. The results of the study were published in the J

Wed, 2018/11/14

Progress in HIV Research in October 2018 (I)

Human immunodeficiency virus (HIV), an AIDS (AIDS, acquired immunodeficiency syndrome) virus, is a virus that causes defects in the human immune system. In 1983, HIV was first discovered in the United States. It is a lentivirus that infects cells of the human immune system and is a type of retrovirus. By destroying the body's T lymphocytes, HIV blocks cellular and humoral immune processes, causing the immune system to deficiency, and causing various diseases to spread in the human body and eventually leading to AIDS. Due to the extremely rapid variation of HIV, it is difficult to produce a spe

Wed, 2018/11/07

BCR: Targeting Collagen XIII Protein Is Expected to Successfully Treat Breast Cancer Metastasis

Recently, researchers from the University of Kentucky found that targeting a protein called collagen XIII may effectively inhibit the metastasis of breast cancer. And the article related was published on Breast Cancer Research. Breast cancer begins in epithelial cells, cells that are arranged in organs and tissues of the body. In general, most of the epithelial cells die when detached from the extracellular matrix. This type of programmed cell death is called anoikis. However, metastatic cancer cells are tolerant to anoikis, which promotes their circulation in the body and begins to grow i

Wed, 2018/11/07

Cancer Res: Cancer Stem Cells May Use Normal Genes to "Do Evil"

CDK1 is a normal protein that drives cells through the replication cycle, while MHC class 1 molecule is also a normal molecule that exhibits a small amount of protein on the cell surface for examination by the immune system; Recently, scientists from the University of Colorado Cancer Center found that a group of cancer cells labeled with MHC class 1 molecule and high levels of CDK1 are extremely unusual. In fact, high levels of MHC class 1 molecule and CDK1 are often the key to the development of certain diseases, such as melanoma, pancreatic cancer, and colon cancer. In fact, these cells may

Tue, 2018/10/16

Nature: "Reconstruct" T cells into the Brain and Attack "Escape" Cancer Cells

For glioblastoma, immunotherapy faces a particular challenge—the blood-brain barrier blocks T cells from entering the brain to prevent brain inflammation that can be life-threatening. This "protective measure" is beneficial under normal conditions, but it prevents T cells from reaching the glioblastoma, leaving immunotherapy useless. On September 5th, Nature published an article entitled "A homing system targets therapeutic T cells to brain cancer", which reveals a new solution from a multi-agency international research team led by scientists at Baylor College of Medicine: Transform T cells

Mon, 2018/10/15

PCGF5 Is Required for Neural Differentiation of Embryonic Stem Cells

Researcher Yao Hongjie from the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research report entitled "PCGF5 is required for neural differentiation of embryonic stem cells" on Nature Communications. This work reveals the molecular mechanism by which polycomb PCGF5 regulates the differentiation of embryonic stem cells into neural precursor cells. Epigenetic modification plays an important role in maintaining stem cell characteristics and cell fate transformation. As an important epigenetic modification factor, polycomb is first discovered in Drosophi