Creative Biomart Blog

Wed, 2018/03/28

Nature Communication: Proteins that Make Difference between Cancerous and Healthy Cells Found

A recent study published in Nature Communication reveals how cancerous cells differ from healthy ones, which paves way for the development of novel strategies for the therapeutic intervention for difficult-to-treat cancers in the future. An international research team discovered a "stop sign"- a mutated protein called PIP-stop, which is overused by tumor cells and can effectively prevent healthy cells from classifying in the way they are designed to. "We have found that there are too many PIP-stops in breast cancer cell, leukemia, lymphoma, and neuroblastoma cells. This will disrupt prot

Sun, 2018/03/25

Recent Research Progress in Heart Disease (II)

(Continued) 4. Nat Commun: Latest research finds the key protein mechanism, which regulates heart and muscle David Giganti et al, Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity, Nature Communications (2018). DOI: 10.1038/s41467-017-02528-7 Scientists from CNIC and Columbia University have identified a key protein regulatory mechanism that regulates skeletal muscle and heart muscle function. Research results have recently been published in Nature Communications. The study was led by Professor Cristian Jorge Alegre-Cebollada, wh

Sun, 2018/03/25

Recent Research Progress in Heart Disease (I)

What we are bringing to you this time is recent advances in heart disease research and we hope it will be useful to you. 1. NEJM: Influenza increases the probability of heart attack by 6 times! Jeffrey C. Kwong et al.Acute myocardial infarction after laboratory-confirmed influenza.N Engl J Med 2018; 378:345-353 DOI: 10.1056/NEJMoa1702090 infection According to a recent study completed by ICRS and PHO researchers, the probability of a heart attack in the first seven days after laboratory-confirmed influenza infection was increased by six times. "Our research is very important be

Thu, 2018/03/15

Cell: TBK1 Is the Blockage to Weight Loss

Highlights TBK1 operates at the intersection of energy expenditure and inflammation TBK1 deficiency attenuates HFD-induced obesity but exaggerates inflammation TBK1 represses energy expenditure by phosphorylating and inhibiting AMPK TBK1 attenuates NF-κB activation and mediates the anti-inflammatory effect of AMPK Do you ever wonder why fat body burns even fewer calories, or why dieting for weight loss always has bottlenecks? That’s because in both cases, our body tries to defend its own weight by regulating energy expenditure. Until now, how this has happened has still been a myst

Tue, 2018/02/27

Science: How Does the “Clock” Protein Work?

As we all know that the human body can function adaptively as the day and night change. And according to a new research from the Perelman School of Medicine at the University of Pennsylvania, a key protein called Rev-erb coordinates the ebb and flow of gene expression by tightening and loosening loops in chromosomes. For the past 15 years, Mitchell A. Lazar et al. have been dedicated to revealing the molecular mechanisms by which Rev-erb proteins regulate the body's molecular clock, metabolic homeostasis, and brain health. “Many studies, including this present one, point to a connection

Tue, 2018/01/30

Breakthrough! Scientists Decipher The Fifteen Years’ Unresolved Secrets of IL-23, Revealed The Key Mechanism of Autoimmune Disease!

Recently an international team led by Professor Savvas Savvides at the VIB-UGent Inflammatory Research Center revealed the key molecular mechanisms of autoimmune and inflammatory diseases including psoriasis, rheumatoid arthritis, and Crohn's disease. By focusing on the immunomodulatory factor IL-23, they found that its proinflammatory activity is strongly dependent on its receptor IL-23R for its structural activation. The research was published in Immunity recently. Psoriasis, rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis have become more prevalent over the past d

Tue, 2018/01/30

Is That True, Women Are More Likely to Survive Than Men?

Current research shows that women live longer than men. And a recent study found baby girls are more likely to survive in famine, epidemics and other unfortunate circumstances, why this happened? The research found that advantage of women may have existed very early. Researchers believe that despite the small differences in gender behavior in infancy, the fact that women also have the advantage in infancy suggests that biology, at least in part, dominates this longevity of women. "Our results bring some light to reveal the gender difference in survival," said Virginia Zarulli of South

Mon, 2018/01/29

Browning of Subcutaneous White Adipose Tissue Provides Outstanding Opportunity for Treatment of Obesity

In a recent study published in the Journal of Experimental Medicine, researchers from Caroline College and other institutions studied mice to elucidate the molecular mechanism of conversion of energy-storing white fat into energy-consuming brown one. Obesity is a major health problem for the global population, affecting people of all ages and increasing the risk of many diseases in humans, including cardiovascular disease, type 2 diabetes and cancers; although obesity can trigger so much health problems, there are currently no drugs or new therapies that are effective in treating obesity an