Creative Biomart Blog

Wed, 2018/11/07

Cancer Res: Cancer Stem Cells May Use Normal Genes to "Do Evil"

CDK1 is a normal protein that drives cells through the replication cycle, while MHC class 1 molecule is also a normal molecule that exhibits a small amount of protein on the cell surface for examination by the immune system; Recently, scientists from the University of Colorado Cancer Center found that a group of cancer cells labeled with MHC class 1 molecule and high levels of CDK1 are extremely unusual. In fact, high levels of MHC class 1 molecule and CDK1 are often the key to the development of certain diseases, such as melanoma, pancreatic cancer, and colon cancer. In fact, these cells may

Tue, 2018/10/16

Nature: "Reconstruct" T cells into the Brain and Attack "Escape" Cancer Cells

For glioblastoma, immunotherapy faces a particular challenge—the blood-brain barrier blocks T cells from entering the brain to prevent brain inflammation that can be life-threatening. This "protective measure" is beneficial under normal conditions, but it prevents T cells from reaching the glioblastoma, leaving immunotherapy useless. On September 5th, Nature published an article entitled "A homing system targets therapeutic T cells to brain cancer", which reveals a new solution from a multi-agency international research team led by scientists at Baylor College of Medicine: Transform T cells

Mon, 2018/10/15

PCGF5 Is Required for Neural Differentiation of Embryonic Stem Cells

Researcher Yao Hongjie from the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research report entitled "PCGF5 is required for neural differentiation of embryonic stem cells" on Nature Communications. This work reveals the molecular mechanism by which polycomb PCGF5 regulates the differentiation of embryonic stem cells into neural precursor cells. Epigenetic modification plays an important role in maintaining stem cell characteristics and cell fate transformation. As an important epigenetic modification factor, polycomb is first discovered in Drosophi

Wed, 2018/09/12

New Mechanism by Which Cancer Cells Inhibit Anti-tumor Immune Responses Revealed

Cancer cells are not just a group of cells that are out of control; for their own survival, they actively participate in the struggle with the immune system. Being able to evade detection by the immune system is a feature of cancer. In a new study, researchers from the University of Pennsylvania found that cancer cells release biological "unmanned aerial vehicles" - small vesicles called exosomes that circulate in the blood. These small vesicles carry the PD-L1 protein, which causes T cells to be exhausted before reaching the tumor - to help with this fight. Although the study focused on metas

Tue, 2018/09/11

Review of the Control of Inflammasome Activation by Phosphorylation

Recently, Zhou Rongbin and Jiang Wei, professors of the Department of Life and Medical Sciences of the University of Science and Technology of China, the Key Laboratory of Natural Immunology and Chronic Diseases of the Chinese Academy of Sciences, and the National Research Center of Hefei Microscale Material Science, were invited to present in the Trends in Biochemical Sciences of Cell. A review article entitled Control of Inflammasome Activation by Phosphorylation was published, which systematically summarizes and discusses the role and mechanism of phosphorylation modification in the activat

Thu, 2018/08/09

Alzheimer's Disease and Insulin—Is There Any Connection?

Johnson & Johnson recently announced that the company has stopped a clinical trial of a new Alzheimer's disease drug due to certain safety issues. This is another failed clinical trial following the announcement of several large clinical trials that have no effect in treating Alzheimer's disease. More and more failure cases tell us that we need to stop and think about how we could find the cause of Alzheimer's disease. In the first analysis of the disease, Doctor Alois Alzheimer from Germany found that some strange changes occurred in the brain of patients who died of this disease. He d

Thu, 2018/08/09

Nat Med: Key Factors Determining the Anticancer Effect of Immunological Checkpoint Therapy

Stimulatory dendritic cells (SDCs) play a key role in stimulating cytotoxic T lymphocytes and promoting immune responses against cancer. Studying the mechanisms that regulate the abundance of SDCs in the tumor microenvironment (TME) will provide new therapeutic strategies. Rencently, researchers from the University of California, San Francisco, studied the abundance in human melanoma and the influencing factors of SDC, and found it was associated with intratumoral expression of the cytokine FLT3LG. The research related was recently published in Nature Medicine, entitled “A natural kille

Mon, 2018/07/02

Immunity: Why Can't HIV Be Cured? Scientists Find the Key Mechanism!

Due to the rapid development of antiretroviral therapy (ART), HIV patients can live longer than before. But even if it is a very effective long-term ART, the HIV virus remains stubbornly incurable, so patients need medication for life. Scientists have been convinced that this is because the HIV virus has created a stubborn virus-infected cell nest that allows HIV to survive indefinitely. A recent study done by researchers at Brigham and Women's Hospital (BWH) explored how the virus acquired its lair. They found that the cell survival mechanism in infected cells was activated, providing potenti