Creative Biomart Blog

Thu, 2017/12/21

Interpretation of the Recent PD-1 Research Progress

PD-1 (programmed cell death protein 1), the programmed death receptor 1, is an important immunosuppressive molecule. Immunomodulation which targets PD-1 is of great importance to anti-tumor, anti-infective, anti-autoimmune diseases, and organ transplant survival. In recent years, scientists have made a number of achievements in the field of PD-1 research. We will share the relevant research here. 1.Science: Scientists confirm that intestinal microbes affect PD-1 / L1 antibody treatment for the first time! Gut microbiota and immunotherapy are convergence DOI: 10.1126/science.aan4236 Th

Fri, 2017/12/01

Highlights of the Journal Cell for Oct, 2017 (III)

(Continued) 9. Draw a four-dimensional map of the self-folding of the human genome Suhas S.P. Rao, Su-Chen Huang, Brian Glenn St Hilaire et al. Cohesin Loss Eliminates All Loop Domains. Cell, 5 October 2017, 171(2):305–320, doi:10.1016/j.cell.2017.09.026 [caption id="attachment_746" align="aligncenter" width="566"] Cohesin Loss Eliminates All Loop Domains[/caption] In a new study, researchers from institutions such as Baylor College of Medicine, Rice University, Stanford University and Broad Institute, constructed the high-resolution four-dimensional map of the human genome fold f

Fri, 2017/12/01

Highlights of the Journal Cell for Oct, 2017 (II)

(Continued) 5. On average, one to ten mutations are sufficient to promote cancer Iñigo Martincorena, Keiran M. Raine, Moritz Gerstung et al. Universal Patterns of Selection in Cancer and Somatic Tissues. Cell, Published online: October 19, 2017, doi:10.1016/j.cell.2017.09.042 [caption id="attachment_738" align="aligncenter" width="565"] Universal Patterns of Selection in Cancer and Somatic Tissues[/caption] In a study of more than 7,500 tumors of 29 cancer types, researchers from the Wellcome Trust Sanger Institute, the European Bioinformatics Institute, and the Francis-Crick Inst

Thu, 2017/11/30

Highlights of the Journal Cell for Oct, 2017 (I)

There are lots of great articles published on Cell in October, let’s share some highlights for you. 1. New discovery on cancer metabolic which challenge the view of nearly 100 years Brandon Faubert, Kevin Y. Li, Ling Cai et al. Lactate Metabolism in Human Lung Tumors. Cell, 5 October 2017, 171(2):358–371, doi:10.1016/j.cell.2017.09.019 [caption id="attachment_729" align="aligncenter" width="374"] lactate metabolism in human lung tumors [/caption] In this new study, researchers from the Children's Medical Center (CRI) at the University of Texas Southwestern Medical Center (CRI) found

Thu, 2017/11/30

DcR3 Is the Key Factor of Endometriosis, Academia Sinica Found

Dr. Shi-Liang Hsieh and his team, from Genomics Research Center, Academia Sinica, has done years of work to find answers to inflammations. Recently, his team has confirmed that inflammation-related DcR3 protein is a key factor to enhance adhesion of endometrial cells, which in turn cause endometriosis, offering an opportunity for the treatment of endometriosis without side effects. Their findings were published in the Journal of Pathology on October 23, 2017. Endometriosis occurs in women of childbearing age and often causes severe menstrual pain. Regard to the symptoms of endometriosis, ex

Tue, 2017/10/31

The Nobel Prize in Chemistry 2017 Awarded to Three Developers of Cryo-Electron Microscopy

The Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for their development of Cryo-Electron Microscopy (cryo-EM), which simplified and improved the imaging of biomolecules’ structure. Did you notice, when you look at biochemical related news a certain period of time before, the pictures of the virus or other biomolecular structure just looked like the rough photos in old 3D horror games, or we say fake 3D models. But it seems to be quite different recent years? Yes, the year of 2013 is the turning point. Scientists can start with a micros

Tue, 2017/10/24

The 2017 Nobel Prize in Physiology or Medicine Announced

2017/10/02, the 2017 Nobel Prize in Physiology or Medicine jointly to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their discoveries of molecular mechanisms controlling the circadian rhythm. They will share 9 million Swedish kroner bonuses award. Jeffrey C. Hall, born in New York in 1945. 1971 received a Ph.D. from the University of Washington, 1971 to 1973 got post-doctoral position at the California Institute of Technology. In 1974 he joined the University of Brandeis. In 2002, he joined the University of Maine. Michael Rosbash, born in 1944 in Kansas City, USA. 1970 recei

Tue, 2017/10/17

Trispecific Antibodies Show Exceptional Potency Against Diverse HIV Viruses

According to the World Health Organization (WHO) statistics, in 2016, a total of about 36 million people suffering from human immunodeficiency disease in the world. Faced such a dilemma, in the efforts of scientists’ study, it seems have a breakthrough. A study on human immunodeficiency virus (HIV) antibody was published in the September 20, 2017 of the journal Science, which is an important milestone in HIV research. Researchers create am antibody with high activity and a wide range applicability based on the genetic engineering technology. It can effectively fight against type I HIV. In g