Creative Biomart Blog

Thu, 2016/05/12

Tau Protein—Not Amyloid—May Be Key Driver of Alzheimer’s Symptoms

Tau proteins are the product of alternative splicing from a single gene, which in humans is designated MAPT (microtubule-associated protein tau) and is located on chromosome 17. They were discovered in 1975 in Marc Kirschner's laboratory at Princeton University. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. Pathologies and dementias of the nervous system such as Alzheimer's disease and Parkinson's disease are associated with tau proteins that have become defective and n

Sat, 2016/05/07

Human Embryo Research Confronts Ethical ‘Rule’

Human embryo development is an important research area for the health of humans. However, there are many limits for Embryonic Development research applications. Here we share an article by Patrick Monahan about Human Embryo Research and Ethical ‘Rule’. This article can be obtained from http://science.sciencemag.org/ (Science 352 (6286), 640. [doi: 10.1126/science.352.6286.640]). The following is full text of this article: It’s easy to obey a rule when you don’t have the means to break it. For decades, many countries have permitted human embryos to be studied in the laboratory only up to 14 da

Mon, 2016/04/25

Precision Medicine: Researchers Push for Personalized Tumor Vaccines

Nowadays, precision medicine has become one of the hot topics in our daily life. Researchers want to treat some diseases according to the information of genes that the patient have in a more efficient way. Do you want to know the opinions of researchers about precision medicine? Here we share an article from nature.com (Nature/ doi:10.1038/nature.2016.19801). The full text is followed: It is precision medicine taken to the extreme: cancer-fighting vaccines that are custom designed for each patient according to the mutations in their individual tumors. With early clinical trials showing promis

Fri, 2016/04/15

JAK2 Inhibitors Target Aggressive Breast Cancers

Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors). Here we’d like to share a latest research about JAK2 gene in breast cancer. This article comes from www.sciencemag.org and www.ScienceTranslationalMedicine.org and you can get all detail from these sites. what's more, Creative Biomart can provide you product related to JAK2 of several sources, grades and formulations for research applications. INTRODUCTION Triple-n

Fri, 2016/04/08

Antidepressant Target-Serotonin Transporter Reveals Its Shape

Prozac and its kin — drugs called selective serotonin reuptake inhibitors (SSRIs) — were first discovered in 1972. They address one hallmark of depression: low levels of the molecule serotonin, which neurons use to signal one another. By preventing a protein called serotonin transporter (SERT) form absorbing the serotonin back into neurons that release it, the drugs boost serotonin levels in the junctions between cells. It is exciting that the structure of the serotonin transporter targeted by several widely used antidepressants — has been solved. The finding, reported on 6 April in Nature (Co

Fri, 2016/04/08

A Collective Route to Metastasis: Seeding by Tumor Cell Clusters

Metastasis is the one of the biggest challenges in cancer therapy. Here we share part of a latest article which discusses the nature of the tumor cells that give rise to metastases by Kevin J. Cheung and Andrew J. Ewald. The origin of this article is Science 08 Apr 2016: Vol. 352, Issue 6282, pp. 167-169 (DOI: 10.1126/science.aaf6546) where you can get the full article. Also Creative Biomart provides molecular tools such as recombinant proteins for tumor metastasis research applications when you need. Abstract: Despite decades of study, there are still many unanswered questions about metastas

Thu, 2016/03/31

Human Induced Pluripotent Stem Cell Transplant to Restore Rabbit Vision

In a new study, Scientists from Osaka University and Cardiff University have confirmed it’s possible to produce several types of ocular tissue in a way that can reflect the development of entire eye. It was confirmed that when transplanted into corneal blindness model animal eyes, these eye tissues can repair the damaged front and restore vision. The researchers said, these findings may pave way for clinical trials of anterior eye transplantation aimed to restore the lost or damaged human eyesight. Previous studies have demonstrated a specific cell type, such as those cells composed of ret

Mon, 2016/03/28

A Platform for Exploring the Core Functions of Life: Design and Synthesis of a Minimal Bacterial Genome

Scientists have design a platform to study the core gene of life organism, using a bacterial genome. What’s more, they obtained some exciting results. Here, we’d like to share the wonderful article expressed by Science Magazine at 25 MARCH 2016 • VOL 351 ISSUE 6280. If you are interested in these research areas, Creative Biomart can provide recombinant proteins for your research. Reference: Hutchison C A, Chuang R Y, Noskov V N, et al. Design and synthesis of a minimal bacterial genome[J]. Science, 2016, 351(6280): aad6253. INTRODUCTION: In 1984, the simplest cells capable of autonomous gr