Creative Biomart Blog

Tue, 2020/05/19

Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer

Recently, in a study published in Cancer Research, scientists from New York University and other institutions have found that a key immune signal may play a previously unknown role in turning off the immune system to attack pancreatic cancer. The researchers found that the immune signaling protein interleukin 1β (IL-1β) can be made and released by pancreatic tumor cells, while it reduces the body's anti-cancer immune response, thereby promoting the growth of pancreatic ductal adenocarcinoma (PDA), a type of cancer that is usually fatal within two years. The researchers say blocking IL-1β ac

Tue, 2020/05/19

Study Found the Global SARS-CoV-2 Is Composed of Six Main Subtypes

The World Health Organization announced the global pandemic of COVID-19 in March 2020, the second pandemic in the 21st century. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an RNA beta coronavirus of the Coronaviridae family. The expansion of virus populations, such as SARS-CoV-2, has accumulated many shared polymorphisms, which has caused confusion in traditional clustering methods. In this case, a method to reduce the complexity of the sequence space occupied by the SARS-CoV-2 population is necessary for accurate clustering. Recently, researchers from the Federal Un

Tue, 2020/05/19

Do You Know How Cells Recognize Uninvited Guests?

Recently, a team led by the University of Bonn discovered how TLR8 plays an important role in defending human cells against invaders. It was found that when RNaseT2 and RNase2 cut the ribonucleic acid (RNA) of bacteria into small fragments with fingerprint characteristics, they were able to be recognized by TLR8 and countermeasures were initiated. And the results are published in the recent issue of Immunity. When bacteria or malaria parasites invade host cells, these cells try to drive off pathogens by releasing ROS. Cells enter a state of emergency, place themselves in an isolated state,

Tue, 2020/05/19

Why SARS-CoV-2 Spread So Easily Among People?

Researchers have identified microscopic features that may make this pathogen more infectious than the SARS virus and can serve as drug targets. With nearly 100,000 people infected with SARS-CoV-2 worldwide, researchers are racing to understand what makes it so easy to spread. Several genetic and structural analyses have identified a key feature of this virus—a protein on the surface—which may explain why it is so susceptible to infect human cells. Other groups are studying how SARS-CoV-2 enters human tissue. Both cellular receptors and viral proteins provide potential targets for drug

Tue, 2020/05/19

Nature: Scientists are Developing Nanovaccines to Fight New Crown Viruses

As infections from SARS-CoV-2 spread from Wuhan, China, to all over the world, researchers are scrambling to develop a vaccine, and life science companies are providing help. On January 28, 2020, a few weeks after the first official report of the first case of coronavirus in 2019, the U.S. Department of Health and Human Services held a press conference in Washington, D.C., saying that SARS-CoV-2 infected thousands of people and that millions of people in China were isolated, but there was no way to treat the virus. Anthony Fauci, director of the National Institute of Allergy and Infectious

Tue, 2020/05/19

Immunity: Activating Tumor-Associated Macrophages to Fight Cancer

Cancer immunotherapy is continuing to revolutionize the means of patient care, bringing hope and good news to patients. However, only a minority of patients respond to treatment, which drives the development of strategies to further address the immunosuppressive tumor environment. In a recent report, Zhou et al developed a method to enhance the immune response to tumors by preventing tumor-associated macrophages (TAMs) from removing dying tumor cells. In tumors and throughout the body, dead cells are cleared by macrophages. These phagocytic immune cells recognize dead cells through a myriad

Mon, 2020/03/30

Nat Immunol: Revealing New Mechanisms of Increased Immunity Following Lung Infection

According to a recent study by the Francis Crick Institute, the immune system response to respiratory infections is constantly changing, depending on the history of previous unrelated infections. The body has two kinds of immunity to infection. Adaptive immunity provides an immune "memory" that can respond rapidly and strongly when the same disease occurs more than once. In contrast, innate immunity provides a broad and less specific first line of defense against all pathogens, and is essential for controlling infections that the body has not previously experienced. The study, publis

Mon, 2020/03/30

PNAS: New Study Shows that Remdesivir Prevents Coronavirus MERS-CoV Infection in Monkeys

In a new study, researchers from the National Institutes of Health reported that the experimental antiviral drug remdesivir (also known as GS-5734) successfully prevented rhesus monkeys infected with the Middle East Respiratory Syndrome (MERS) coronavirus (MERS-CoV) from becoming ill from this virus infection. Giving remdesivir before infection can prevent them from getting sick, while giving this drug after they are infected can improve their condition. The results were published in the journal PNAS, entitled "Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque m