| Cat.No.: | PE-1812 |
| Product Name: | NCOR2/SMRT (human recombinant) |
| Description: | Nuclear receptor corepressor 2 (NcoR2) is a transcriptional corepressor that plays an essential role in the regulation of development and metabolism. Histone deacetylases (HDACs) can mediate nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. However, HDACs are primarily responsible for catalyzing the deacetylation of core histones. HDAC3, a class I HDAC related to the yeast HDAC Rpd, is inactive alone and requires binding with the deacetylase activation domain (DAD) of NcoR2 for activation. The deacetylation of core histones by HDACs results in the tightening of nucleosomal integrity, restriction of access to transcription factors, and the suppression of gene transcription. In addition, HDACs mediate other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-κB, p300, Stat3, p53, and the retinoblastoma (Rb) protein. The modification of chromatin structure and other non-histone proteins by HDACs serves to control many complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Thus, dysregulation of HDACs, leading to an imbalance of acetylation and deacetylation, may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 39 kDa |
| Species: | human |
| Alternative Names: | CTG Repeat Protein 26;Nuclear Receptor Corepressor 2;Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor;SMAP270;SMRT;T3 Receptor-Associating Factor;Thyroid-Retinoic-Acid-Receptor-Associated Corepressor;TRAC |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0019 | SMARCA4 Polyclonal Antibody | Inquiry |
| ◆ Research Kits | ||
| EKIT-0046 | HDAC3/NCOR1 fluorometric drug discovery Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0046 | Recombinant Human NCOR1, GST-tagged | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0063 | Recombinant Human SMARCC2 293 Cell Lysate | Inquiry |
| EL-0064 | Recombinant Human SMARCB1 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| NCAPD3 | NCAPH2 | NCOA1 | NCOA2 |
| NCOA3 | NCoA4 | NCOR1 | ncor2 |
| SMAD3 | SMAD4 | SMARCA1 | SMARCA2 |
| SMARCA4 | SMARCA5 | SMARCA6 | SMARCAD1 |
| SMARCAL1 | SMARCB1 | SMARCC1 | SMARCC2 More > |
| SMARCD1 | SMARCD2 | SMARCD3 | SMARCE1 |
| SMC1-α | SMC3 | SMC4 | SMCHD1 |
| SMCX | SMN | SMN1 | SMN2 |
| SMOC2 | SMRT | SMT3 | SMUG1 |
| SMURF2 | SMYD1 | SMYD2 | SMYD2B |
| SMYD3 | SMYD4 | SMYD5 | |
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