| Cat.No.: | PE-1806 |
| Product Name: | Polybromo-1D bromodomain 1 (human recombinant) |
| Description: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The PBRM1 gene encodes the bromodomain-containing protein Polybromo-1D (PBRM1). PBRM1 contains six bromodomains and is a component of the SWI/SNF complex, PBAF. PBAF is targeted to acetylated sites in chromatin by the PBRM1 bromodomains, where it plays a role in cell cycle regulation and tumor suppression. This product contains the bromodomain 1 region of PBRM1. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 42.8 kDa |
| Purity: | ≥95% |
| Species: | human |
| Formulation: | 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol and 5 mM β-mercaptoethanol |
| Alternative Names: | BAF180;BRG1-associated factor 180;hPB1;MGC165155;MGC165156;PB1;PBRM1;Protein Polybromo-1 |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0006 | Bromodomain Ligand 4 | Inquiry |
| Related Gene / Proteins | |||
| BRCA1 | BRCA2 | BRCC3 | BRD |
| brd1 | brd2 | brd3 | brd4 |
| BRD7 | BRD8 | brd9 | brdt |
| BRL | BRM | BRMS1 | BRPF1 |
| BRPF2 | brpf3 | BRWD1 | BRWD3 |
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