| Cat.No.: | PE-1472 |
| Product Name: | Recombinant Human MSH6, GST-tagged |
| Product Overview: | MSH6 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 51 amino acids (350-400 a.a.) having a total Mw of 33 kDa. Human MSH6 is fused to a GST tag and purified by proprietary chromatographic techniques. |
| Description: | This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Species: | Human |
| Formulation: | Sterile Filtered clear solution. MSH6 is supplied in 50mM Tris-HCl, pH-7.5, 10mM L-glutathione (reduced). |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | MSH6 mutS homolog 6 [ Homo sapiens (human) ] |
| Gene ID NCBI: | 2956 |
| Synonyms: | MSH6; GTBP; HSAP; p160; GTMBP; HNPCC5; mutS homolog 6; DNA mismatch repair protein Msh6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein |
| mRNA Refseq: | NM_000179 |
| Protein Refseq: | NP_000170 |
| MIM: | 600678 |
| Chromosome Location: | 2p16 |
| Function: | contributes_to ADP binding; contributes_to ATPase activity; contributes_to MutLalpha complex binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0104 | Recombinant Human MSL1 Lysate | Inquiry |
| EL-0193 | Recombinant Human MSL3 293 Cell Lysate | Inquiry |
| EL-0194 | Recombinant Human MSL3 293 Cell Lysate | Inquiry |
| EL-0218 | Recombinant Human MSH6 293 Cell Lysate | Inquiry |
| EL-0227 | Recombinant Human MSL2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| MS4A7 | MSH2 | MSH3 | MSH5 |
| MSH6 | MSI2 | MSL1 | MSL2 |
| MSL3 | MSP58 | MST1 | MSY2 |
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