| Cat.No.: | PE-1363 |
| Product Name: | Recombinant Human Elongation Protein 3 Homolog (S. Cerevisiae), GST-tagged |
| Product Overview: | Recombinant full-length human ELP3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | ELP3 is the catalytic subunit of the histone acetyltransferase (HAT) elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons. The knockdown of ELP3 by antisense morpholinos in zebrafish embryos resulted in dose-dependent shortening and abnormal branching of motor neurons with no concomitant morphologic abnormalities. ELP3 knockdown also impairs paternal DNA demethylation as indicated by reporter binding, immunostaining, and bisulfite sequencing. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 86 kDa |
| Purity: | > 75 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | Full length |
| Concentrations: | 0.1 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | ELP3 elongation protein 3 homolog (S. cerevisiae) [ Homo sapiens ] |
| Gene ID NCBI: | 55140 |
| Official Symbol: | ELP3 |
| Synonyms: | ELP3; elongation protein 3 homolog (S. cerevisiae); KAT9; FLJ10422; elongator complex protein 3; hELP3; OTTHUMP00000128319; OTTHUMP00000225327; OTTHUMP00000225330; EC 2.3.1.48 |
| mRNA Refseq: | NM_018091 |
| Protein Refseq: | NP_060561 |
| MIM: | 612722 |
| UniProt ID: | Q9H9T3 |
| Chromosome Location: | 8p21.1 |
| Function: | contributes_to DNA binding; N-acetyltransferase activity; histone acetyltransferase activity; iron-sulfur cluster binding; metal ion binding; phosphorylase kinase regulator activity; protein binding; transferase activity, transferring acyl groups |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0191 | Recombinant Human ELP3 Cell Lysate | Inquiry |
| EL-0199 | Recombinant Human ELP2 293 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0314 | ELAVL3 Polyclonal Antibody | Inquiry |
| EAb-1079 | ELP3 Polyclonal Antibody, HRP Conjugated | Inquiry |
| EAb-1082 | ELP3 Polyclonal Antibody, FITC Conjugated | Inquiry |
| Related Gene / Proteins | |||
| ELAVL3 | ELE1 | Elk-1 | ELP2 |
| ELP3 | ELP4 | ||
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