| Cat.No.: | PE-1349 |
| Product Name: | Recombinant Human Sin3A-Associated Protein, 18kDa, His-tagged |
| Product Overview: | SAP18 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 173 amino acids (20- 172 a.a.) and having a molecular mass of 19.7 kDa. The SAP18 is purified by proprietary chromatographic techniques. |
| Description: | SAP18 is a component of the histone deacetylase complex which has a significant role in the regulation of eukaryotic gene expression. SAP18 directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression once bound to the promoter. SAP18 plays an important part in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. Histone acetylation is significant in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation is catalyzed by multisubunit complexes. SAP18 is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. SAP18 is a component of a splicing-dependent multiprotein EJC (exon junction complex) placed at splice junction on mRNAs. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Sterile Filtered colorless solution. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Species: | Human |
| Formulation: | The SAP18 solution contains 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 30% glycerol, 1mM DTT. |
| Tag: | His |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SAP18 Sin3A-associated protein, 18kDa [ Homo sapiens ] |
| Gene ID NCBI: | 10284 |
| Official Symbol: | SAP18 |
| Synonyms: | SAP18; Sin3A-associated protein, 18kDa; SAP18P; 2HOR0202; MGC27131; sin3-associated polypeptide, p18; cell growth inhibiting protein 38; histone deacetlyase complex subunit SAP18; sin3A-associated protein, 18kDa; SAP18p; Histone deacetylase complex subunit SAP18; Sin3-associated polypeptide, 18 kDa; Sin3-associated polypeptide p18; Cell growth-inhibiting protein 38; GIG38; OTTHUMP00000018107 |
| mRNA Refseq: | NM_005870 |
| Protein Refseq: | NP_005861 |
| MIM: | 602949 |
| UniProt ID: | O00422 |
| Chromosome Location: | 13q12.11 |
| Function: | protein binding; transcription corepressor activity |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0034 | SALL1 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0058 | 3-Deazaadenosine | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0152 | Recombinant Human SAP30L 293 Cell Lysate | Inquiry |
| EL-0155 | Recombinant Human SAP30BP 293 Cell Lysate | Inquiry |
| EL-0164 | Recombinant Human SAP30 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| SAH | SALL1 | SALL4 | SAP130 |
| SAP145 | SAP18 | SAP30 | SAP30BP |
| SAP30L | SART3 | SATB1 | SATB2 |
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